JAHA:房颤患者多种血液生物标志物与卒中风险

2021-07-30 MedSci原创 MedSci原创

使用血液生物标志物或多标志物风险评分可显著改善房颤患者卒中风险预测。

房颤与卒中风险增加相关;可用的风险预测工具只有中等的准确性。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员假设循环中卒中风险生物标志物可能会改善房颤患者的卒中风险预测。

卒中地理和种族差异原因(REGARDS)研究是一项前瞻性队列研究,涉及30239名年龄≥45岁的黑人和白人成年人。这项针对卒中病例的嵌套研究和队列的随机样本包含了175名参与者(63%为女性,37%为黑人成人),他们具有基线房颤和可用的血液生物标志物数据。

多指标评分与卒中风险

这些参与者在5.2年内发生了81次缺血性卒中。根据人口统计学、卒中危险因素和华法林使用情况进行调整后,以下生物标志物与卒中风险相关(最高三分位数与最低三分位数相比的风险比[HR]和95% CI):胱抑素C为3.16;1.04-9.58;因子VIII抗原为2.77;1.03-7.48;白细胞介素-6为9.35;1.95-44.78;NT-proBNP(B型利钠肽前体N末端)为4.21;1.24–14.29。研究人员基于最高三分位数血液生物标志物数量开发了多标志物风险评分;与没有相比,1个、2个和3个以上升高的血液生物标志物调整后卒中HR分别为1.75(0.57-5.40)、4.97(1.20-20.5)和9.51(2.22-40.8)。将多标志物风险评分与CHA2DS2VASc评分相结合,净重分类改善为0.34(95%CI为0.04-0.65)。

由此可见,该研究的结果表明,使用血液生物标志物或多标志物风险评分可显著改善房颤患者卒中风险预测。

原始出处:

Matthew J. Singleton.et al.Multiple Blood Biomarkers and Stroke Risk in Atrial Fibrillation: The REGARDS Study.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020157

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    2021-08-01 智智灵药
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  5. 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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
  6. 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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
  7. 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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 土豆你个马铃薯

    信息 我摸旅游

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1841710, encodeId=63a61841e1087, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Feb 19 21:39:53 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268594, encodeId=7668126859488, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031444, encodeId=d5951031444e0, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046100, encodeId=bc711046100cd, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1841710, encodeId=63a61841e1087, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Feb 19 21:39:53 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268594, encodeId=7668126859488, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, 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level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sun Aug 01 10:39:53 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004101, encodeId=13e610041018b, content=信息 我摸旅游, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Fri Jul 30 23:12:45 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026924, encodeId=81101026924df, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031444, encodeId=d5951031444e0, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046100, encodeId=bc711046100cd, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 心介

    房颤,临床上碰到很多哦

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031444, encodeId=d5951031444e0, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046100, encodeId=bc711046100cd, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jul 30 22:39:53 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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