JAMA子刊:重度抑郁症和双相情感障碍与大麻使用障碍存在共同的生理机制

2022-06-27 MedSci原创 MedSci原创

研究结果证实了CUD的家族聚集性。患有BP-II的亲属患CUD的风险增加,表明CUD可能与BP-II有共同的基础病症。

全球大麻使用障碍(CUD)正在增加。有关情绪障碍和CUD合并的潜在机制可能有助于预防CUD。为了研究CUD和情绪障碍亚型的共同发生和家族聚集情况,来自美国的学者开展了一项研究,结果发表在jama psychiatry杂志上。

在这项以华盛顿特区都市区为基础的横断面研究中,通过半结构化的诊断访谈和家族史报告,评估受试者和亲属的终生DSM-IV障碍。通过混合效应模型,调整年龄、性别、招募来源以及合并的情绪、焦虑和其他物质使用障碍,估计CUD的家族聚集和与情绪障碍的共同聚集。

2004年5月至2020年8月,在大华盛顿特区的社区筛查中,共招募了586名成年患者(186名双相情感障碍患者;55名CUD患者)和698名一级亲属(91名双相情感障碍患者;68名CUD患者)。主要结果和措施是一级亲属的终身CUD。

在586名受试者中,395名(67.4%)是女性;在698名亲属中,437名(62.6%)是女性。原告的平均(SD)年龄为47.5(15.2)岁,亲属为49.6(18.0)岁。患者(55[9.4%])的CUD与亲属的CUD增加有关(OR=2.64; P = 0.02)。同时,患者(72人[12.3%])的双相情感障碍II(BP-II)也与亲属中CUD的风险增加有关(aOR=2.57; P=0.04)。

然而,患者的双相情感障碍I(114[19.5%])和重度抑郁症(192[32.8%])与亲属中的CUD没有显著关联。在亲属中,CUD与BP-II(aOR=4.50; P = 0.002)、重度抑郁症(aOR,3.64; P < .001)相关。BP-II与CUD的家族性共同聚集因合并焦虑症而减弱。此外,有BP-II家族史和个人史的亲属中CUD发生率最高。在大多数情况下,患者和亲属的情绪障碍亚型的发病时间先于CUD。

研究结果证实了CUD的家族聚集性。患有BP-II的亲属患CUD的风险增加,表明CUD可能与BP-II有共同的基础病症。再加上抑郁症和狂躁症在CUD发病方面的时间优先性,这些发现突出了BP-II干预作为CUD预防的潜在作用。

 

 

参考文献:

Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study. JAMA Psychiatry. Published online June 01, 2022. doi:10.1001/jamapsychiatry.2022.1338

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    2022-06-27 kcb069
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    2022-06-25 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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