Lasers Surg Med:强脉冲光和光动力疗法联合10%盐酸氨酚酸凝胶可有效治疗光损伤

2022-02-25 MedSci原创 MedSci原创

光动力疗法(PDT)是一种治疗浅表非黑色素瘤皮肤癌、光化性角化病(AK)和痤疮的有效方法。既往研究显示,PDT可改善色斑、皮肤粗糙、肤色黯淡和细小皱纹,治疗光损伤皮肤。

光动力疗法(PDT)是一种治疗浅表非黑色素瘤皮肤癌、光化性角化病(AK)和痤疮的有效方法。既往研究显示,PDT可改善色斑、皮肤粗糙、肤色黯淡和细小皱纹,治疗光损伤皮肤。近日,发表于Lasers Surg Med的一项随机试验评估使用新型的10%盐酸氨基乙酰丙酸(ALA)凝胶(10% ALA凝胶)和BF-RhodoLED®光(635纳米;37焦耳/厘米2)与强脉冲光(IPL)相结合的光动力疗法(PDT)的疗效和安全性,以增强对肩部光损伤皮肤的医疗和审美改善。

这是一项单站点的前瞻性、随机性、个体内分离胸腔试验,研究共纳入20名患有中度至重度肩颈部光损伤的女性受试者。两侧胸部随机一侧接受ALA-PDT + IPL治疗,而对侧则只进行ALA-PDT治疗。三位盲评员使用全球美学改善量表(GAIS)评估治疗后光损伤处的美学改善情况。

结果,最终18名受试者(98%)完成了这项研究,两名参与者退出了研究,9名参与者完成了所有4次随访。分析结果显示,随访24周后,ALA-PDT+IPL治疗侧(3.57±0.09)的GAIS结果优于仅ALA-PDT治疗侧(2.89±0.09,P < 0.001)。

综上所述,该使用10%的盐酸ALA纳米乳胶与IPL相结合的ALA-PDT对肩部进行光子嫩肤,取得了令人满意的效果,与单独使用ALA-PDT相比,取得了具有统计学上的显著差异。安全性评估结果证明没有明显的不良反应。而且,该研究结果还表明,相对较低的IPL通量足以实现这些结果。

原始出处:

Michael Abrouk, et al., Medical and aesthetic improvement of photodamaged skin by the combination of intense pulsed light and photodynamic therapy with 10% aminolevulinic acid hydrochloride gel. Lasers Surg Med. 2022 Jan;54(1):62-65. doi: 10.1002/lsm.23460.  

 

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    2022-05-11 anminleiryan
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    2022-02-25 lishizhe
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