BMC Cancer：AFP可作为肝癌放疗后预测指标

2015-12-21 Seven L 译 MedSci原创

研究者进行了一向研究，评估小的肝细胞性肝癌（HCC）患者进行立体定向放射治疗（SBRT）后，甲胎蛋白(AFP)作为预后指标的意义。该回顾性研究纳入了165名原发或复发HCC患者，均进行了SBRT，经筛查后选择了77名符合以下纳入标准的患者：1）SBRT术前AFP > 20 ng/mL ；2）SBRT术后三个月内复查AFP。使用倾向得分匹配分析使潜在混杂因素最小化。正常AFP值定义为其含量 ≤

研究者进行了一项研究，评估小肝细胞癌（HCC）患者进行立体定向放射治疗（SBRT）后，甲胎蛋白(AFP)作为预后指标的意义。

该回顾性研究纳入了165名原发或复发HCC患者，均进行了SBRT，经筛查后选择了77名符合以下纳入标准的患者：1）SBRT术前AFP > 20 ng/mL ；2）SBRT术后三个月内复查AFP。使用倾向得分匹配分析使潜在混杂因素最小化。正常AFP值定义为其含量 ≤ 20 ng/mL。使用Kaplan-Meier方法分析患者整体生存期和(OS)和无进展生存期 (PFS)。

研究数据显示，37(48.1%)名患者AFP正常（正常组），还有40 (51.9 %) 名AFP值异常的患者（异常组）。两组患者3年整体存活率分别为62.0 %和44.0 % (p = 0.023；3年无进展生存率分别为27.9 %和12.0 % (p = 0.019)；第3年两组患者肿瘤局部控制率分别为97.2 %和94.7 % (p = 0.579)。倾向得分匹配队列（25对）的分析显示，正常组的OS和PFS显著长于异常组(OS：p = 0.017；PFS：P=0.049)；局部控制率均为100%。

研究结果显示，对于小肝细胞癌患者，立体定向放射治疗术后3个月内AFP值恢复正常，可以作为该类OS和PFS的预测指标。不过只有对SBRT术前AFP值升高的患者进行AFP监测才有意义。

原始出处：

Jung J, Yoon SM,et al.Alpha-fetoprotein normalization as a prognostic surrogate in small hepatocellular carcinoma after stereotactic body radiotherapy: a propensity score matching analysis.BMC Cancer. 2015 Dec 18;15(1):987.

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#插入话题

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2015-12-30 mxj1971619

#AFP#

44 0
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2016-11-13 ms3025846204744509

#BMC#

29 0
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2015-12-30 樱桃树

会不会纳入标准有偏倚

162 0
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2015-12-29 xyfg98

有不同吗？

137 0
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2015-12-29 xyfg98

一直都是啊

144 0
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2015-12-28 wzf990214

有意思

124 0
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2015-12-28 wzf990214

赞一个

93 0
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2015-12-26 hixiaoluo

值得看，好好收藏

89 0
[GetPortalCommentsPageByObjectIdResponse(id=1633254, encodeId=10aa1633254b4, content=<a href='/topic/show?id=08a220e6ce' target=_blank style='color:#2F92EE;'>#AFP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2076, encryptionId=08a220e6ce, topicName=AFP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9b922043063, createdName=mxj1971619, createdTime=Wed Dec 30 23:14:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974644, encodeId=065519e4644d4, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Nov 13 22:14:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50376, encodeId=6b1a503e6d3, content=会不会纳入标准有偏倚, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc9a1675161, createdName=樱桃树, createdTime=Wed Dec 30 09:50:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50187, encodeId=a0785018e08, content=有不同吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:15:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50186, encodeId=d38b501864f, content=一直都是啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:14:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49749, encodeId=460f49e4962, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 00:25:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49750, encodeId=9c3449e5037, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 00:25:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48170, encodeId=ac36481e040, content=值得看，好好收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 15:43:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406991, encodeId=9eaf14069910d, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Wed Dec 23 04:14:00 CST 2015, time=2015-12-23, status=1, ipAttribution=)]
2015-12-23 anminleiryan

#预测指标#

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