Circulation:冠脉搭桥术后房颤提示脑血管意外风险增加

2020-10-11 星云 MedSci原创

术后房颤(pAF)是冠状动脉旁路移植术的一种常见并发症。pAF是否与脑血管意外(CVA)风险增加有关仍不确定。本研究通过对动脉血管再生试验(ART)的10年预后结果进行事后分析,以研究pAF和CVA长

术后房颤(pAF)是冠状动脉旁路移植术的一种常见并发症。pAF是否与脑血管意外(CVA)风险增加有关仍不确定。本研究通过对动脉血管再生试验(ART)的10年预后结果进行事后分析,以研究pAF和CVA长期风险之间的关系。

本次分析最终共纳入了3023位ART的受试者(排除了未进行手术的、有房颤病史以及没有pAF信息的患者),其中734位(24.3%)出现pAF,剩余的2289位患者保持窦性心律。

A:CVA的总体累计风险风险;B:出院后的CVA累计风险

10年时,有pAF和窦性心律的患者的CVA的累计发生率分别为6.3%(4.6%–8.1%)vs 3.7% (2.9%–4.5%)。pAF是10年时CVA的独立预测因素(风险比 1.53 [95% CI, 1.06–2.23]; P=0.025),即使排除入院期间发生的CVAs(1.47 [95% 1.02–2.11]; P=0.04)。

A:心血管死亡率;B:全因死亡率

冠状动脉搭桥手术后发生术后房颤(pAF)的患者,具有较高的脑血管意外风险。这些发现挑战了pAF是良性并发症的概念。

原始出处:

Umberto Benedetto, et al. Postoperative Atrial Fibrillation and Long-Term Risk of Stroke After Isolated Coronary Artery Bypass Graft Surgery. Circulation. 2020;142:1320–1329

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    2020-10-17 ms5000000069254713

    不用研究也知道

    1

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  5. 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    2020-10-13 咻凡

    服用ACEi可降低成年高血压妇女平滑肌瘤的发生几率。

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Oct 12 07:43:46 CST 2020, time=2020-10-12, status=1, ipAttribution=)]
    2020-10-13 zzc2214
  8. [GetPortalCommentsPageByObjectIdResponse(id=2066839, encodeId=dae4206683947, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon May 03 04:30:11 CST 2021, time=2021-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892589, encodeId=96cf892589fa, content=不用研究也知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201003/146bb24b4baf4558b152e7d9125d7af2/56cb7300721e49f599f03a82e34e98bc.jpg, createdBy=c5a25410119, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30966, encryptionId=696730966a0, topicName=冠脉搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710114309336, createdName=yese, createdTime=Tue Oct 13 14:30:11 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891745, encodeId=7510891e459a, content=冠状动脉搭桥手术后发生术后房颤(pAF)的患者,具有较高的脑血管意外风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Tue Oct 13 11:26:50 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891376, encodeId=9af18913e69d, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Oct 12 07:43:46 CST 2020, time=2020-10-12, status=1, ipAttribution=)]
    2020-10-13 yese
  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30966, encryptionId=696730966a0, topicName=冠脉搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710114309336, createdName=yese, createdTime=Tue Oct 13 14:30:11 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891745, encodeId=7510891e459a, content=冠状动脉搭桥手术后发生术后房颤(pAF)的患者,具有较高的脑血管意外风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Tue Oct 13 11:26:50 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891376, encodeId=9af18913e69d, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Oct 12 07:43:46 CST 2020, time=2020-10-12, status=1, ipAttribution=)]
    2020-10-13 Lexi

    冠状动脉搭桥手术后发生术后房颤(pAF)的患者,具有较高的脑血管意外风险。

    0

  10. 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likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Oct 13 15:03:46 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492387, encodeId=faa0149238e7f, content=<a href='/topic/show?id=a251569194f' target=_blank style='color:#2F92EE;'>#搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56919, encryptionId=a251569194f, topicName=搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a28924986, createdName=zzc2214, createdTime=Tue Oct 13 14:30:11 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552929, encodeId=47a81552929b7, content=<a href='/topic/show?id=696730966a0' target=_blank style='color:#2F92EE;'>#冠脉搭桥#</a>, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Oct 12 07:43:46 CST 2020, time=2020-10-12, status=1, ipAttribution=)]
    2020-10-12 qingfengqishi5

    学习了,学习了

    0

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冠状动脉旁路移植术( CABG)是治疗冠心病常见的血运重建手段。CABG 后心脏康复是一项综合的、整体的全程医疗管理模式,包括运动治疗、二级预防用药、营养支持、心理管理、戒烟等方面,CABG 后规范的心脏康复对于降低再住院率,提高患者运动能力和生活质量以及预防心血管不良事件等方面具有积极意义。因此,为了促进我国CABG 后心脏康复的规范化发展,国家心血管病中心、CABG 后心脏康复专家共识编写委员

NEJM:心肌活力与缺血性心肌病远期预后的关系

研究认为,冠状动脉旁路移植术对心肌活力与缺血性心肌病患者的长期预后无关,心肌活力与左室收缩功能改善有关,而与治疗无关,但这种改善与长期存活无关

JAHA:缺血性心肌病患者冠状动脉旁路移植术的早期和中期结局

由此可见,缺血性心肌病患者冠状动脉旁路移植术与较高的早期复合结局相关。然而,5年生存率良好。左心室功能缺乏改善是晚期死亡率的强预测因子。

JAMA:桡动脉vs隐静脉移植与冠状动脉旁路移植术后长期心血管不良预后风险

研究发现在接受冠状动脉旁路移植术的患者中,使用桡动脉移植与隐静脉相比,心血管不良预后风险更低