骨肉瘤预后个体化预测模型列线图的建立

2015-06-09 黄纲,董忠信,谢显彪,尹军强,邹昌业,王永谦,王晋,沈靖南 中华骨科杂志

目的 通过对骨肉瘤患者的临床、病理学、影像学及随访资料进行预后因素分析,建立骨肉瘤预后预测模型列线图,并验证其准确度。方法 收集1998至2008年确诊且符合入组标准的235例骨肉瘤患者组成建模组,2009年的55例骨肉瘤患者组成验证组。单因素生存分析采用 Kaplan-Meier法绘制生存曲线,Log-rank法进行统计学分析;应用Cox比例风险模型进行多因素分析,确定独立预后因子;然后应

目的 通过对骨肉瘤患者的临床、病理学、影像学及随访资料进行预后因素分析,建立骨肉瘤预后预测模型列线图,并验证其准确度。方法 收集1998至2008年确诊且符合入组标准的235例骨肉瘤患者组成建模组,2009年的55例骨肉瘤患者组成验证组。单因素生存分析采用 Kaplan-Meier法绘制生存曲线,Log-rank法进行统计学分析;应用Cox比例风险模型进行多因素分析,确定独立预后因子;然后应用R软件 建立预测模型列线图,内部验证运用Bootstrap法,外部验证运用验证组,一致性指数(C-index)用来评价模型准确度,并绘制出列线图预测和实 际观察的五年生存率校准曲线。结果 建模组和验证组五年总体生存率分别为46.1%±6.7%和61.8% ±12.9%。多因素分析结果显示,病理性骨折、入院时碱性磷酸酶水平、肿瘤大小、肿瘤分期和术后化疗次数是独立预后因素。校准曲线显示列线图预测与实际 观察的五年生存率有很好的一致性。列线图预测五年生存率的C-index为0.74(95%CI,0.70~0.78),明显高于Enneking分期系 统。应用验证组进行外部验证,列线图、Enneking分期

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    2015-06-11 18619c0a62m

    什么?_?

    0

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    2015-06-10 午夜星河

    不知

    0

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    2015-06-10 summer474cn

    这是什么情况

    0

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    2015-06-10 summer474cn

    怎么算是点啊!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1981403, encodeId=c77d1981403f0, content=<a href='/topic/show?id=15a8319384a' target=_blank style='color:#2F92EE;'>#列线图#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31938, encryptionId=15a8319384a, topicName=列线图)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Feb 28 11:03:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27204, encodeId=f6072e20478, content=什么?_?, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 22:02:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262711, encodeId=f8b71262e117b, content=<a href='/topic/show?id=52941002359d' target=_blank style='color:#2F92EE;'>#预测模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100235, encryptionId=52941002359d, topicName=预测模型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jun 11 14:03:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435309, encodeId=248a143530984, content=<a href='/topic/show?id=9a5c212e88f' target=_blank style='color:#2F92EE;'>#个体化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21278, encryptionId=9a5c212e88f, topicName=个体化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jun 11 14:03:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26871, encodeId=9b5d268e16b, content=不知, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Jun 10 12:51:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26839, encodeId=0af22683987, content=这是什么情况, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 10 08:10:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26840, encodeId=4cd12684085, content=怎么算是点啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 10 08:10:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26841, encodeId=2d2026841e7, content=我发现医学也在不停的靠近数学!, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 10 08:10:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26776, encodeId=766c26e76af, content=。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c08106028, createdName=alicelee, createdTime=Wed Jun 10 00:08:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26777, encodeId=12e826e77b1, content=。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c08106028, createdName=alicelee, createdTime=Wed Jun 10 00:08:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
    2015-06-10 summer474cn

    我发现医学也在不停的靠近数学!

    0

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    2015-06-10 alicelee

    0

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    2015-06-10 alicelee

    0

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