PLoS One:红细胞分布宽度与脑白质疏松症严重程度独立相关

2016-04-05 phylis 译 MedSci原创

背景:红细胞分布宽度(RDW)是全血计数检查中的一种常规的血液学检查的参数,RDW已被公认为各种医疗条件的预后标志物,尤其是心血管事件。研究者评估RDW与脑白质疏松症相关;脑的一般影像学与脑卒中和痴呆风险增加相关。在本研究中,研究者纳入了1006名非卒中患者,这些患者进行脑MRI检查及常规的全血检查包括RDW。应用Fazekas量表检测基于液体衰减反转恢复图像的脑白质疏松症的严重程度,将严重程度分

背景:红细胞分布宽度(RDW)是全血计数检查中的一种常规的血液学检查的参数,RDW已被公认为各种医疗事件的预后标志物,尤其是心血管事件。

研究者评估RDW与脑白质疏松症的关系;脑的一般影像学与脑卒中和痴呆风险增加相关。

在本研究中,研究者纳入了1006名非卒中患者,这些患者进行脑MRI检查及常规的全血检查包括RDW。应用Fazekas量表检测基于液体衰减反转恢复图像的脑白质疏松症的严重程度,将严重程度分为轻度(Fazekas量表:0-1)及重度脑白质疏松症(Fazekas量表:2-3)。应用单因素和多因素Logistic回归模型评估脑白质疏松症的严重程度的独立危险因素。平均年龄为64.34±9.11岁,平均RDW为12.97±0.86%。28.83%的患者脑白质疏松症的严重程度(Fazekas量表≥2)。在多因素logistic回归分析,与RDW第一四分位数(<12.5%)相比,第四四分位RDW(> 13.3%)与脑白质疏松症的严重程度显著相关(校正OD,1.87;95%CI,1.20-2.92)。

校正糖化血红蛋白和其他血液学指标后。这些结果表明,RDW与脑白质疏松症的严重程度独立相关。

原文出处:

Lee HB, Kim J, et al. Red Blood Cell Distribution Width Is Associated with Severity of Leukoaraiosis. PLoS One. 2016 Feb 26.


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    2016-04-09 Kathyli

    统计力量的伟大

    0

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    2016-04-09 Kathyli

    统计力量的伟大

    0

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    2016-04-06 yilibaisha

    真的啊血常规要全面解读了

    0

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