IBD: 焦虑和抑郁症状与小儿克罗恩病患者未来疾病活动无关

2021-07-14 MedSci原创 MedSci原创

对患有克罗恩病 (CD) 的成年人的研究表明,在疾病活动恶化之前,CD患者的心理健康状况大部分会出现恶化。但是这样的现象是不是也会在儿童CD患者中出现。

      对患有克罗恩病 (CD) 的成年人的研究表明,在疾病活动恶化之前,CD患者的心理健康状况大部分会出现恶化。但是这样的现象是不是也会在儿童CD患者中出现,目前还没有研究进行报道,因此,本项研究旨在评估抑郁症和/或焦虑症是否预示着儿童 CD 疾病活动的恶化。

 

      通过炎症性肠病的全球合作网络,9 至 17 岁患有 CD 的儿童完成了患者报告结果测量信息系统 (PROMIS) 的填写和克罗恩病活动指数 (sCDAI)的评估。然后使用一般线性模型,研究人员检查了基线 PROMIS 小儿焦虑和抑郁症状评分如何与随后的 sCDAI 评分(平均调查间隔 6.4 个月)存在相关性。模型包括基线 PROMIS 小儿焦虑和抑郁症状评分、基线 sCDAI、性别、年龄、父母教育、种族/民族和先前的 IBD 相关手术。

 

      研究总共纳入159 名 CD 儿童(平均年龄 14 岁,45% 女性,84% 处于基线缓解期)。我们发现基线 PROMIS 小儿焦虑评分与随后的 sCDAI 之间没有关联(OR:-0.89;95% CI -4.81 至 3.03)。基线 PROMIS 小儿抑郁症状评分与未来的 sCDAI 无关(OR: <0.01;95% CI -4.54 至 4.53)。在基线缓解患者的亚组分析中,仍然不存在相关性。

 

      本项研究证实焦虑和抑郁症状都与儿童 CD 的后续疾病活动无关。这些发现与成人 IBD 研究形成强烈对比。

 

 

原始出处:

Erica J Brenner. Et al. Anxiety and Depressive Symptoms Are Not Associated With Future Pediatric Crohn’s Disease Activity. Inflammatory Bowel Diseases.2021.

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    2021-07-16 bnurmamat
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    2021-07-14 ms4000000260930224

    学习了

    0

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    2021-07-14 王旭锋

    劳劳碌碌热热后

    0

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    2021-07-14 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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    2021-07-14 Flora0708

    很认真学习了

    0

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    2021-07-14 医鸣惊人

    认真学习了

    0

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