npj Precision Oncology :研究员发现了一种胰腺癌的生物标志物!

2021-07-05 MedSci原创 MedSci原创

研究人员发现了一种可用于帮助诊断胰腺癌的蛋白质, (PTX3) 可能是一种敏感且特异的生物标志物,能够区分胰腺癌和其他癌症。

胰腺癌是最致命的常见癌症,每年在英国夺走大约 9,400 人的生命。大多数胰腺癌病例在癌症处于晚期时被诊断出来,因为在疾病的早期阶段缺乏特定的症状,并且缺乏可以帮助早期检测的特定生物标志物。 mayoclinic 在临床上,计算机断层扫描 (CT) 扫描通常用于诊断胰腺癌“虽然CT可以检测出胰腺肿块的存在,但无法将胰腺癌与其他非癌性胰腺疾病区分开来。这在临床实践中经常造成诊断困境。 伦敦玛丽女王大学的研究人员发现了一种可用于帮助诊断胰腺癌的蛋白质,这项新研究的结果表明,一种名为pentraxin 3 (PTX3) 可能是一种敏感且特异的生物标志物,能够区分胰腺癌性和其他癌症。该研究结果于 2021年6月29号发表在npj Precision Oncology 上。 在这项研究中,研究员分析了来自 267 名捐献者的血液样本,其中包括来自 PDAC 患者的 140 份样本,研究人员测量了胰腺导管腺癌 (PDAC) 患者(最常见的胰腺癌类型)以及健康志愿者或患有其他非癌性胰腺疾病患者的血清血液样本中的 PTX3 水平。 并发现在 PDAC 患者的血清样本中,PTX3 水平显著更高

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    2021-11-14 zhmscau
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2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038347, encodeId=0af5103834e3f, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jul 05 02:59:29 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2022-05-16 zhouqu_8
  5. 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  6. 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14:59:29 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996438, encodeId=1fa199643889, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Mon Jul 05 15:18:33 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996300, encodeId=94bf996300e8, content=用PTX3做指标,也是要同时针对癌细胞和基质才有效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibu7hwJqpmHiaJgLLmJmcwp0WDTxWI3vqPBO1Mloq21VBOPqziapyibYatvd2QWHWicolL1vbVZHgpRQ/132, createdBy=d16a2107341, createdName=JZ Yang, createdTime=Mon Jul 05 07:43:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038347, encodeId=0af5103834e3f, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jul 05 02:59:29 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1988516, encodeId=c0cc1988516ef, content=<a href='/topic/show?id=1637e3378a8' target=_blank style='color:#2F92EE;'>#研究员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73378, encryptionId=1637e3378a8, topicName=研究员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Sun Nov 14 05:59:29 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993624, encodeId=32f2199362455, content=<a href='/topic/show?id=17124e60f1' target=_blank style='color:#2F92EE;'>#CIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4760, encryptionId=17124e60f1, topicName=CIS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, 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14:59:29 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996438, encodeId=1fa199643889, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Mon Jul 05 15:18:33 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996300, encodeId=94bf996300e8, content=用PTX3做指标,也是要同时针对癌细胞和基质才有效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibu7hwJqpmHiaJgLLmJmcwp0WDTxWI3vqPBO1Mloq21VBOPqziapyibYatvd2QWHWicolL1vbVZHgpRQ/132, createdBy=d16a2107341, createdName=JZ Yang, createdTime=Mon Jul 05 07:43:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038347, encodeId=0af5103834e3f, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jul 05 02:59:29 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2021-07-05 1e1ad8bdm04(暂无匿称)

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1988516, encodeId=c0cc1988516ef, content=<a href='/topic/show?id=1637e3378a8' target=_blank style='color:#2F92EE;'>#研究员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73378, encryptionId=1637e3378a8, topicName=研究员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Sun Nov 14 05:59:29 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993624, encodeId=32f2199362455, content=<a href='/topic/show?id=17124e60f1' target=_blank style='color:#2F92EE;'>#CIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4760, encryptionId=17124e60f1, topicName=CIS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, 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14:59:29 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996438, encodeId=1fa199643889, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Mon Jul 05 15:18:33 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996300, encodeId=94bf996300e8, content=用PTX3做指标,也是要同时针对癌细胞和基质才有效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibu7hwJqpmHiaJgLLmJmcwp0WDTxWI3vqPBO1Mloq21VBOPqziapyibYatvd2QWHWicolL1vbVZHgpRQ/132, createdBy=d16a2107341, createdName=JZ Yang, createdTime=Mon Jul 05 07:43:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038347, encodeId=0af5103834e3f, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jul 05 02:59:29 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2021-07-05 JZ Yang

    用PTX3做指标,也是要同时针对癌细胞和基质才有效果

    0

  10. 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2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038347, encodeId=0af5103834e3f, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jul 05 02:59:29 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2021-07-05 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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JAMA Surg:导管内乳头粘液性肿瘤积极监测过程中与恶性病变相关的动态因素研究

导管内乳头粘液性肿瘤患者积极监测过程中,基线存在高危特征以及随访过程中出现新需关注特征患者的恶性进展风险较高,而出现黄疸患者的浸润癌风险高

Cell Death Differ:miR-30d抑制有氧糖酵解作用抑制胰腺癌的发生

胰腺导管腺癌(PDAC)作为最致命的人类癌症之一,其特点是高糖酵解速率,以确保其在营养不良高缺氧的微环境中仍能够发展。

2021 ASCO大会日程预告1(6月4日)

开幕式上,ASCO主席洛里-皮尔斯博士(Lori Pierce)将发表主题演讲,并邀请卫生政策方面的专家作为演讲嘉宾。

拓展阅读

Cell Metab:中山大学郑健/王力勤/林东昕发现QDPR缺陷驱动胰腺癌的免疫抑制

该研究发现,在胰腺导管腺癌(PDACs)中,调节生物蝶呤代谢的关键酶—醌类二氢蝶呤还原酶(QDPR)的缺乏会导致代谢物二氢生物蝶呤(BH2)的积累,并降低四氢生物蝶呤(BH4)与BH2的比值。

胰腺癌高频突变基因汇总

胰腺癌高频突变基因汇总

抗癌新进展,使用计算机、人工智能和激光来治疗胰腺癌就要开始了!

今天我们给大家报道的是一个新科技,通过计算机技术和激光来实现胰腺癌的治疗,这个是欧盟资助的项目,旨在通过人工智能(AI)来改善胰腺癌患者的前景。

Lancet Oncol:不可切除或转移性胰腺癌迎来突破性进展!溶瘤病毒疗法LOAd703 安全可行

在晚期PDAC患者中联合使用LOAd703和NAB-P加吉西他滨是可行且安全的。在这种新型化学免疫治疗方法的基础上,LOKON001 的第二项研究正在进行中。

JNCI:二甲双胍激活抗癌免疫,使胰腺癌术后5年生存率提高3倍

最近,一项由荷兰研究团队在《美国国家癌症研究所杂志》(JNCI)上发表的最新分析显示,二甲双胍可能成为抗击“癌中之王”——胰腺癌的关键利器。在接受先行手

Dev Cell:浙江大学孙毅团队发现全新促癌通路,提出胰腺癌治疗新靶点

该研究发现UBE2F对于KRAS突变的人胰腺癌细胞的生长是必不可少的。

2023 ASO实践指南:可切除、边缘可切除及局部晚期胰腺癌的管理

美国肿瘤外科协会(SSO,Society of Surgical Oncology) · 2023-11-19

晚期胰腺癌介入治疗临床操作指南(试行)(第六版)

中国癌症研究基金会介入医学委员会 · 2022-04-13

晚期胰腺癌介入治疗临床操作指南(试行) (第三版)

中国癌症研究基金会介入医学委员会 · 2019-01-30

晚期胰腺癌介入治疗临床操作指南( 试行) ( 第二版)

中国癌症研究基金会介入医学委员会 · 2018-02-20

晚期胰腺癌介入治疗临床操作指南(试行)-下

中国癌症研究基金会介入医学委员会 · 2016-12-20