Diabetes Care:1/5的1型糖尿病患者共患自身免疫性疾病

2020-03-19 MedSci MedSci原创

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,这项研究的目的是量化与芬兰的非糖尿病患者相比,1型糖尿病(T1D)成人自身免疫性甲状腺功能减退和甲亢、Addison病、乳糜泻和

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,这项研究的目的是量化与芬兰的非糖尿病患者相比,1型糖尿病(T1D)成人自身免疫性甲状腺功能减退和甲亢、Addison病、乳糜泻和萎缩性炎的额外风险。
 
该研究纳入了来自芬兰糖尿病肾病(FinnDiane)研究的4758例T1D患者和12710例非糖尿病对照个体。通过将数据与1970年至2015年期间的芬兰全国健康登记系统相关联,确定自身免疫性疾病(AD)。
 
2015年随访结束时FinnDiane研究参与者的中位年龄为51.4岁(四分位间距为42.6-60.1岁),糖尿病病程的中位时间为35.5年(26.5-44.0年)。在T1D患者中,有22.8%的患者至少再患有一种AD,其中包括31.6%的女性和14.9%的男性。与对照组相比,T1D患者发生甲状腺功能减退症、甲状腺功能亢进症、乳糜泻、Addison病和萎缩性炎的几率分别为3.43(95%CI为3.09-3.81)、2.98(2.27-3.90)、4.64(3.71-5.81)、24.13(5.60-104.03)以及5.08(3.15-8.18)。与男性相比,女性的相应OR分别为2.96(2.53-3.47)、2.83(1.87-4.28)、1.52(1.15-2.02)、2.22(0.83-5.91)和1.36(0.77-2.39)。T1D晚期发病和衰老增加了甲状腺功能减退的风险,而T1D早年发病增加了乳糜泻的风险。
 
由此可见,这是世界上T1D发病率最高国家中量化T1D成年患者共患AD风险的最大研究之一。该研究的结果突出了对T1D患者持续筛查其他AD的重要性。
 
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    2020-11-11 zhaojie88
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    2020-03-19 misszhang

    谢谢MedSci提供最新的资讯

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