NEJM:巴洛沙韦酯用于家庭流感暴露后预防

2020-07-09 MedSci原创 MedSci原创

巴洛沙韦酯可降低家庭环境中流感患者暴露后感染风险。

巴洛沙韦酯是一种聚合酶酸性蛋白(PA)核酸内切酶抑制剂,对单纯流感具有治疗效果,近日研究人员考察了巴洛沙韦酯对家庭环境中流感暴露的预防效果。
 
研究人员进行了一项多中心、双盲、随机、安慰剂对照试验,以评估巴洛沙韦酯在2018-2019年流感季日本流感患者家庭接触者暴露后的预防效果,参与者随机接受巴洛沙韦酯或安慰剂。主要终点是临床流感,经逆转录酶-聚合酶链反应检测证实,为期10天。
 
545流感患者和752名家庭接触者随机接受巴洛沙韦或安慰剂。流感患者中,95.6%感染了甲型流感病毒,73.6%小于12岁,52.7%接受了巴洛沙韦治疗。巴洛沙韦组374例,安慰剂组375例接受评估,巴洛沙韦组发生临床流感的比例明显低于安慰剂组(1.9% vs 13.6%,调整后的风险比为0.14)。巴洛沙韦对高危、儿科和未接种疫苗等亚组有效。无论症状如何,巴洛沙韦组感染流感的风险均低于安慰剂组(校正后的风险比为0.43)。两组的不良事件发生率相似(巴洛沙韦组为22.2%,安慰剂组为20.5%)。在巴洛沙韦组中,分别在10名(2.7%)和5名(1.3%)参与者检测到病毒PA I38T/M或E23K突变,不能证明上述变异是从接受巴洛沙韦治疗的患者传染给接触者,但不能排除向巴洛沙韦组组内传播的可能性。
 
研究认为,巴洛沙韦酯可降低家庭环境中流感患者暴露后感染风险。
 
原始出处:
 
Hideyuki Ikematsu et al. Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts. N Engl J Med, July 8, 2020.

 

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    2021-03-19 ms6000000252401279

    好内容

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  2. [GetPortalCommentsPageByObjectIdResponse(id=949622, encodeId=0b2b949622f9, content=好内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37e5423044, createdName=ms6000000252401279, createdTime=Fri Mar 19 23:27:01 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915066, encodeId=e4e691506625, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 22:13:29 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915057, encodeId=661d91505ef2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 22:02:47 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885186, encodeId=e96e8851869d, content=<a href='/topic/show?id=021b65306fb' target=_blank style='color:#2F92EE;'>#流感#</a>的神药<a href='/topic/show?id=c6e710390531' target=_blank style='color:#2F92EE;'>#巴洛沙韦#</a>,一粒搞定,现在国内应该上市了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=454, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65306, encryptionId=021b65306fb, topicName=流感), TopicDto(id=103905, encryptionId=c6e710390531, topicName=巴洛沙韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Sep 14 15:53:28 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029161, encodeId=ce802029161ce, content=<a href='/topic/show?id=cc106020142' target=_blank style='color:#2F92EE;'>#暴露后预防#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60201, encryptionId=cc106020142, topicName=暴露后预防)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/lGEyfsKnIkkH93xUPMrUUycLh2XOfJJsphwPsVqDx8somSOepIFy9QE0MVAwDW3AS7V1epJ4tbPL9ADJLicvm8A/132, createdBy=b5132500067, createdName=ms55066533437992, createdTime=Wed Jun 16 23:19:58 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035337, encodeId=87a8103533e03, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jul 09 21:19:58 CST 2020, time=2020-07-09, status=1, ipAttribution=)]
    2021-01-09 zb1235672

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    2021-01-09 zb1235672

    学习了

    0

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    2020-09-14 lovetcm

    #流感#的神药#巴洛沙韦#,一粒搞定,现在国内应该上市了吧

    0

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    2020-07-09 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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