Ann Rheum Dis:类风湿性关节炎的疾病活动性、细胞因子、趋化因子和糖尿病风险

2021-01-20 xiangting MedSci原创

在RA患者中,疾病活动性高和细胞因子/趋化因子水平升高与患DM的风险升高相关。

目前已知类风湿性关节炎(RA)患者出现糖尿病(DM)的风险升高。这项研究旨在确定RA疾病活动性(包括评估特定的细胞因子和趋化因子)与DM的关联。

参与者是退伍军人事务部类风湿性关节炎登记中经医师确诊的RA成年患者。作为临床治疗的一部分,纵向进行了疾病活动性和临床评估。入组时测量了血清中的30种细胞因子和趋化因子。DM是根据使用诊断代码和药物的算法定义的。使用多因素Cox比例风险模型评估临床因素与DM发病之间的关联。调整年龄、性别、种族、吸烟、体重指数(BMI)和用药情况后,评估了细胞因子/趋化因子与DM之间的关联。

结果如下:入组时没有DM的1866例RA患者中,随访9223患者-年后,130例出现了DM。疾病活动性评分(DAS28)-C反应蛋白(CRP)升高、肥胖、年龄大和男性与患DM的风险升高相关,而目前吸烟和使用甲氨蝶呤具有保护性作用。使用甲氨蝶呤的患者患DM的风险较低。几种细胞因子/趋化因子与DM发病率独立相关,其中包括白介素(IL)-1、IL-6和巨噬细胞衍生的细胞因子/趋化因子(HR范围为1.11–1.26)。这些关联与DAS28-CRP无关。

由此可见,在RA患者中,疾病活动性高和细胞因子/趋化因子水平升高与患DM的风险升高相关。未来可以研究对高危人群进行靶向治疗是否可以预防DM的发生。

原始出处:

Joshua F Baker. Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis. Ann Rheum Dis. January 2021.

 

 

 

 

 

 

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style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334274, encodeId=630913342e4d9, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483705, encodeId=b9a41483e05ac, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-08-24 zhaojie88
  5. 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createdName=ms4964546379600229, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483705, encodeId=b9a41483e05ac, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-02-03 gqylhd

    都是慢性免疫性疾病

    0

  6. 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  7. 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style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334274, encodeId=630913342e4d9, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483705, encodeId=b9a41483e05ac, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Jan 22 04:20:58 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-22 lmm397
  8. 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  9. 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  10. 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J Gastro: 糖尿病患者肝细胞癌的发生几率分析

在全球范围内,肝癌是第七大最常见的癌症,也是第四大最常见的死因。在2008年,估计约有77%的肝癌病例归因于乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)感染。

BMJ:SGLT-2抑制剂或GLP-1受体激动剂治疗糖尿病的临床优势

SGLT-2抑制剂和GLP-1受体激动剂可降低糖尿病患者的心血管及肾脏事件风险

JAMA Netw Open:新型减肥药Bimagrumab 对2型糖尿病和肥胖成人体脂质量的影响

用bimagrumab阻断激活素受体可以为管理伴有过度肥胖的2型糖尿病患者提供一种新的药物治疗方法。

爱豆也扛不住的中年肥胖很可怕!糖尿病风险增加2倍,老年痴呆风险增3倍

最近一档热播综艺《哈哈哈哈哈》节目中,鹿晗的脸上明显长了一圈肉,下巴也变得圆润,鹿晗这一变胖,被狠狠的关注了一波,网友称这绝对是中年发胖。