Eur Heart J:乳房X线检查结果与心脏代谢疾病风险和死亡率相关

2021-08-02 MedSci原创 MedSci原创

乳房X线检查结果的特征与心脏代谢风险和死亡率相关。该研究的结果强化了这样一观念,即结合乳房X线检查结果特征和其他乳腺癌危险因素,可以成为一种新型用于评估参加乳房X线筛查女性心脏代谢健康状况的工具。

近年来,在常规乳房X线检查中发现的微钙化与女性的心脏代谢性疾病相关。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在通过一个大型筛选队列系统地评估微钙化和其他乳房X线检查结果特征与心脏代谢性疾病风险和死亡率之间的关系,并了解潜在的遗传因素。

这项研究纳入了来自瑞典前瞻性乳房X线摄影筛查队列(KARMA)中的57867名女性和49583名姐妹。心脏代谢疾病的诊断、死亡率和药物是通过与瑞典人口登记中心进行链接来提取的,几乎没有丢失的数据。

在心脏代谢表型相关性研究中,研究人员发现,大量的微钙化与多种心脏代谢疾病的风险增加相关,特别是在已有心脏代谢疾病的女性中。相比之下,致密乳房与较低的心脏代谢疾病发生率相关。重要的是,在KARMA研究女性的姐妹中也观察到了类似的关联,表明乳房X线检查结果的特征和心脏代谢特征之间可能存在遗传重叠的机制。最后,研究人员观察到微钙化与既往有心脏代谢性疾病患者死亡率增加相关(风险比和95%置信区间为1.79(1.24-2.58),P=0.002)。研究人员在没有心脏代谢性疾病的女性中未观察到这些效应。

由此可见,乳房X线检查结果的特征与心脏代谢风险和死亡率相关。该研究的结果强化了这样一观念,即结合乳房X线检查结果特征和其他乳腺癌危险因素,可以成为一种新型用于评估参加乳房X线筛查女性心脏代谢健康状况的工具。

原始出处:

Felix Grassmann.et al.Mammographic features are associated with cardiometabolic disease risk and mortality.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab502

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    2021-08-04 piaojinhua
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1998585, encodeId=b063199858518, content=<a href='/topic/show?id=b2b66251e52' target=_blank style='color:#2F92EE;'>#检查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62517, encryptionId=b2b66251e52, topicName=检查结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Sat Mar 26 08:49:50 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298057, encodeId=2296129805e96, content=<a href='/topic/show?id=c42d18892ad' target=_blank style='color:#2F92EE;'>#X线#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18892, encryptionId=c42d18892ad, topicName=X线)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337235, encodeId=6b69133e2351f, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357755, encodeId=bbd3135e755cd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402020, encodeId=3d451402020ae, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473285, encodeId=ec8d14e3285c0, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563499, encodeId=05f21563499cb, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Aug 04 13:49:50 CST 2021, time=2021-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004813, encodeId=b6fa1004813d5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Aug 03 07:29:39 CST 2021, time=2021-08-03, status=1, ipAttribution=)]
    2021-08-04 zhaojie88
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    2021-08-04 slcumt
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    2021-08-03 学医无涯

    学习一下

    0

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