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PNAS：血液来源蛋白驱动脑炎症和斑块沉积

2018-09-28 海北 MedSci原创

阿尔兹海默炎症
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阿尔茨海默病（AD）患者脑中最主要的两个特征是β-淀粉样蛋白（Aβ）斑块的沉积和炎症。这些病理背后的机制仍然未知，但有证据表明炎症可能早于Aβ的沉积。

阿尔茨海默病（AD）患者脑中最主要的两个特征是β-淀粉样蛋白（Aβ）斑块的沉积和炎症。这些病理背后的机制仍然未知，但有证据表明炎症可能早于Aβ的沉积。
此外，免疫激活越来越多地被认为是疾病发病机理的主要原因，并且涉及全身性炎症的疾病，例如感染，衰老，肥胖，动脉粥样硬化，糖尿病和抑郁症是AD发展的风险因素。
纤溶酶原（PLG）是主要在肝脏中合成的血液蛋白质，当切割成其活性形式时，纤溶酶（PL）在纤维蛋白溶解，伤口愈合，细胞信号传导和炎症调节中起作用。
最近，来自洛克菲勒大学的研究人员发现，血液中的PL是脑炎症作用和AD病理的调节剂。通过反义寡核苷酸技术耗尽AD小鼠模型血浆中的PLG，可以显着改善AD病理学，并减少脑中神经胶质细胞的活化，而通过α-2-抗纤溶酶（A2AP）反义寡核苷酸处理，增加PL活性，可以加剧大脑的免疫反应和斑块沉积。
这些研究表明，外周PL在介导神经免疫细胞活化和AD进展中的关键作用，并且可以提供与已知的AD发展相关的全身性炎性风险因子的联系。

原始出处：

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    2019-01-19 爆笑小医

    #PNAS#

    0

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    2018-09-29 ms3994565386320060

    #斑块#

    0

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    2018-09-29 ms1779634646866130

    #脑炎#

    0

  4. 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createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Sep 29 21:47:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343584, encodeId=6228134358424, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Sat Sep 29 21:47:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347088, encodeId=00b734e08803, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:18 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347087, encodeId=056034e0872f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:15 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347086, encodeId=ee3c34e086f7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:11 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347085, encodeId=68af34e085cf, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:08 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347084, 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GetPortalCommentsPageByObjectIdResponse(id=347044, encodeId=27f534e044d2, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 28 07:31:52 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2018-09-28 xiaotao112411

    学习学习学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1856221, encodeId=78d5185622142, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Jan 19 12:47:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330099, encodeId=86541330099a2, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:11 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347085, encodeId=68af34e085cf, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:08 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347084, 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GetPortalCommentsPageByObjectIdResponse(id=347044, encodeId=27f534e044d2, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 28 07:31:52 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2018-09-28 xiaotao112411

    学习学习学习

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:11 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347085, encodeId=68af34e085cf, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Sep 28 08:35:08 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347084, 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GetPortalCommentsPageByObjectIdResponse(id=347044, encodeId=27f534e044d2, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 28 07:31:52 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2018-09-28 xiaotao112411

    学习学习学习

    0

  7. 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    2018-09-28 xiaotao112411

    学习学习学习

    0

  8. 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    2018-09-28 xiaotao112411

    学习学习学习

    0

  9. 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    2018-09-28 xiaotao112411

    学习学习学习

    0

  10. 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    2018-09-28 kafei

    学习了谢谢

    0

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