J Periodontal Res:使用欧米茄-3脂肪酸作为非手术牙周治疗的辅助手段,是否能为牙周炎的治疗带来额外益处?

2022-07-21 MedSci原创 MedSci原创

牙周炎是一种慢性炎症性疾病,其标准疗法是龈下清创和有效控制龈上生物膜。然而,即使机械性清创在短期内呈现出良好的效果,这些益处可能无法长期保持,特别是易感个体。

牙周炎是一种慢性炎症性疾病,其标准疗法是龈下清创和有效控制龈上生物膜。然而,即使机械性清创在短期内呈现出良好的效果,这些益处可能无法长期保持,特别是易感个体。 补充欧米茄-3(n-3)多不饱和脂肪酸(PUFA)作为牙周治疗的辅助疗法,已经在几个临床试验和一个先前的系统回顾中进行了调查。近日,发表于J Periodontal Res的一项系统回顾和荟萃分析旨在探究使用膳食补充欧米伽-3脂肪酸作为非手术牙周治疗的辅助手段与单独的非手术牙周治疗相比在治疗牙周炎方面是否有额外的益处。

研究纳入了对非手术牙周治疗与膳食欧米伽-3脂肪酸相结合的随机临床试验(RCTs),至少有3个月的随访。在MEDLINE、EMBASE和LILACS数据库中搜索了截至2021年10月发表的文章。进行随机效应荟萃分析,以确定治疗后临床附着水平(CAL)、探诊深度(PPD)、探诊出血(BOP)和牙龈指数(GI)的变化。

最终,研究人员从电子数据库中检索到的884篇可能相关的论文中选择了10篇RCT进行定性分析,其中8篇RCT被纳入了荟萃分析。分析结果显示,与使用欧米茄-3脂肪酸相关的PPD明显减少和AL显著增加。汇总估计显示,PPD总体上显著减少0.42 mm(95% CI 0.15, 0.68),CAL增加0.58 mm(95% CI 0.24, 0.92)。

综上所述,该研究结果表明,在患有牙周炎的人中,使用欧米茄-3脂肪酸膳食补充剂作为非手术牙周治疗的辅助手段,与单独的非手术牙周治疗相比,可以提供额外的CAL增加和PPD减少的益处。

原始出处:

Nidia C Castro Dos Santos, et al., Does the use of omega-3 fatty acids as an adjunct to non-surgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta-analysis. J Periodontal Res. 2022 Jun;57(3):435-447. doi: 10.1111/jre.12984.  

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