Diabetologia:血清肌腱蛋白- c与主要不良心血管事件增加和2型糖尿病患者的死亡独立相关:一个法国前瞻性队列

2020-07-20 MedSci原创 MedSci原创

肌腱蛋白- c (TN-C)是一种细胞外基质糖蛋白,并在炎症和心血管疾病中高度表达。目前,在2型糖尿病患者中,还没有针对血清TN-C进行的专门研究。

肌腱蛋白- c (TN-C)是一种细胞外基质糖蛋白,并在炎症和血管疾病中高度表达。目前,在2型糖尿病患者中,还没有针对血清TN-C进行的专门研究。在这项研究中,我们假设2型糖尿病患者登记时血清TN-C升高与随访期间死亡风险和主要不良CV事件(MACE)的增加有关。

我们采用前瞻性单中心队列连续2型糖尿病患者(SUivi Rénal, DIAbète de type 2 et GENEtique] cohort),以全因死亡作为主要终点,而以MACE (MACE, CV死亡、非致死性心肌梗死或中风)作为次要终点。采用传统风险因素校正后的比例风险模型和相对综合判别改进(rIDI)来评估TN-C对这些风险因素的增量预测价值。

我们对1321名个体(58%为男性,平均年龄64±11岁)进行了89个月的监测。在随访期间,442人死亡,497人有MACE。多因素Cox分析显示,血清TN-C浓度与死亡风险增加相关(HR / 1 SD: 1.27 [95% CI 1.17, 1.38];p < 0.0001)和MACE(每1 SD的HR: 1.23 [95% CI 1.13, 1.34];p < 0.0001)。在传统危险因素的基础上使用TN-C浓度,预测全因死亡风险(rIDI: 8.2%;p = 0.0006)和MACE (rIDI: 6.7%;p = 0.0014)显著改善,但幅度不大。

研究结果表明,在2型糖尿病患者中,血清中TN-C浓度的升高与死亡和ACE的发生独立相关。因此,将TN-C作为预后生物标志物可以改善这些个体的风险分层。

原始出处:

Barnabas Gellen,Nathalie Thorin-Trescases,Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort

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style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399941, encodeId=54a31399941e2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, 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encryptionId=b5cf81043ed, topicName=肌腱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d6810483958, createdName=丁鹏鹏, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533203, encodeId=cbdb153320320, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=)]
    2020-07-22 neurowu
  8. 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  9. 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style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399941, encodeId=54a31399941e2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, 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encryptionId=b5cf81043ed, topicName=肌腱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d6810483958, createdName=丁鹏鹏, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533203, encodeId=cbdb153320320, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Wed Jul 22 05:07:28 CST 2020, time=2020-07-22, status=1, ipAttribution=)]
    2020-07-22 丁鹏鹏
  10. 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