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Clinica Chimica Acta：2型糖尿病中脂蛋白相关磷脂酶A2与下肢动脉疾病的关系

2020-08-09 MedSci原创 MedSci原创

2型糖尿病2型糖尿病患者
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脂蛋白相关磷脂酶A2 (Lp-PLA2)与心血管疾病的发生密切相关，而在2型糖尿病(T2DM)中，有关Lp-PLA2与下肢动脉疾病(LEAD)的相关性在既往研究中并不一致。

脂蛋白相关磷脂酶A2 (Lp-PLA2)与心血管疾病的发生密切相关，而在2型糖尿病(T2DM)中，有关Lp-PLA2与下肢动脉疾病(LEAD)的相关性在既往研究中并不一致。因此，本研究旨在探讨Lp-PLA2的升高是否与T2DM患者中铅的发生有关。

研究共纳入519例T2DM患者(173例LEAD，346例非LEAD)。记录人口统计学、病史、血脂、糖化血红蛋白、Lp-PLA2和踝肱指数(ABI)进行分析。

LEAD组的糖尿病持续时间，女性患病率，高血压患病率和Lp-PLA2浓度显著高于非LEAD组（糖尿病持续时间：15 [10–20] vs 8 [2–12] 年，女性患病率：49.13％vs 38.73％，高血压患病率：58.38％vs 38.11％，Lp-PLA2：145 [108-178] vs 125 [107-138] ng / ml，p <0.05）。 Lp-PLA2与ABI呈负相关（r = -0.308，p <0.001）。 多元逻辑回归分析结果表明，血清Lp-PLA2是LEAD发生的独立因素（比值：1.018 [1.007-1.029]，P = 0.001）。

研究表明，2型糖尿病患者血清Lp-PLA2浓度升高与LEAD有关。它们是LEAD发生的独立危险因素。

原始出处：

Xin-YueXu，Li Guo，Association between lipoprotein-associated phospholipase A2 and lower extremity arterial disease in type 2 diabetes mellitus

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    2020-10-21 446798725_87912765

    #下肢动脉疾病#

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    2020-09-14 windight

    #CTA#

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    2020-12-11 swallow

    #下肢动脉#

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    2020-08-11 juliusluan79

    #脂蛋白#

    0

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    2020-08-10 misszhang

    谢谢MedSci提供最新的资讯

    0

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