Gastroenterology:胆汁酸螯合剂IW-3718辅助治疗难治性胃食管反流病

2020-06-28 MedSci原创 MedSci原创

研究发现,在标准PPI治疗基础上,添加1500mg IW-3718可显著减少难治性胃食管反流病患者烧心和反流症状

难治性胃食管反流病(GERD)严重影响了患者的生活质量,统计发现,在接受标准剂量质子泵抑制剂(PPIs)治疗的GERD患者中约30%仍有症状。近日研究人员评估了胆汁酸螯合剂IW-3718作为PPI治疗的辅助手段的有效性和安全性。
 
280名确诊的GERD患者参与研究。按食管炎状态分层,患者在标准剂量PPI基础上,随机给予安慰剂或IW-3718(500、1000或1500 mg),每日两次。主要终点是从基线到第8周的每周烧心严重程度评分变化,研究人员还分析了从基线检查到第8周每周反流频率得分百分比变化。
 
从基线检查到第8周,安慰剂组、500 mg组、1000 mg组和1500 mg IW-3718组的每周胃灼热严重程度评分的平均变化分别为46.0%、49.0%、55.1%和58.0%。1500 mg IW-3718组与安慰剂组的治疗差异为11.9%。1500 mg IW-3718与安慰剂组相比,从基线检查到第8周每周反流频率得分的平均变化减少为17.5%。最常见的不良反应是便秘,未发生与药物有关的严重不良事件。
 
研究发现,在标准PPI治疗基础上,添加1500mg IW-3718可显著减少难治性胃食管反流病患者烧心和反流症状。
 
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    2021-11-07 1482963am12暂无昵称

    学习的

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    2021-01-01 许安
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  5. 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  6. 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  7. 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  8. 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createdName=chaojitidian, createdTime=Tue Jun 30 09:34:47 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528670, encodeId=2a7515286e0fa, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Tue Jun 30 09:34:47 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
    2020-06-30 zhouqu_8
  9. 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    2020-06-30 freve

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由于标准三联疗法对幽门螺杆菌的根除率较低,因此有人建议添加铋盐用于一线根除幽门螺杆菌。本项研究旨在评估铋与标准的含克拉霉素的三联疗法在根除幽门螺杆菌感染中的有效性和安全性。

J Gastroenterology: 长期使用质子泵抑制剂与胰腺癌的关系

质子泵抑制剂(PPI)的长期安全性受到越来越多的质疑。本项研究的目的是评估长期PPI使用者中胰腺癌的风险。

THER ADV GASTROENTER: 右兰索拉唑为基础的三联疗法可以根治幽门螺杆菌感染

右兰索拉唑已显示对于治疗胃食管反流疾病有效。然而,关于其对根除幽门螺杆菌的功效的数据很少。因此,本项研究的目的是评估右兰索拉唑作为三联疗法的基础在根除幽门螺杆菌的功效。

AP&T: 质子泵抑制剂对消化道微生物组的影响

质子泵抑制剂(PPI)被广泛用于治疗与酸有关的上消化道疾病。但是,大量的观察性研究引起了人们对与PPI相关的不良事件的担忧。近年来,来自下一代测序研究的数据表明,PPI影响肠道菌群的组成,而平衡的肠道微生物组对于维持健康至关重要。因此,本项研究的目的是审查下一代测序研究中有关PPI对肠道微生物组的作用的可用证据,并讨论PPI引起的营养不良对健康和疾病的潜在影响。

Gastroenterology:症状性及质子泵抑制剂难治性胃食管反流病发病率研究

通过人群调查,研究人员发现胃食管反流病症状十分常见:5名参与者中有2人在过去存在GERD症状,3人中有1人在过去一周有过GERD症状。研究人员还发现一半的PPI使用者有持续的症状。鉴于GERD对生活质