JCEM:咖啡因、咖啡类型与卵巢癌风险

2019-07-10 xing.T 网络

由此可见,研究人员发现咖啡因、不同类型的咖啡与卵巢癌风险之间没有显著关联。

关于咖啡因和不同类型咖啡摄入与卵巢癌风险相关的前瞻性研究得出了相互矛盾的结果。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究的目的是饮食中咖啡因摄入量、不同类型咖啡摄入与卵巢癌风险之间关联的队列研究进行剂量反应荟萃分析。

研究人员检索了PubMed、Medline、ISI Web of Science、Scopus和EMBASE,以确定2018年10月之前发表的相关文章。前瞻性队列研究认为咖啡因和不同类型的咖啡作为暴露变量和卵巢癌作为主要结局变量或作为结局变量之一被纳入本系统评价和荟萃分析。两位作者独立筛选了9344篇出版文献。荟萃分析共纳入14项队列研究。两位作者独立提取了数据。任何分歧都是在与主要调查员协商后得到解决的。

该分析总共纳入了940359名参与者,其中4434名卵巢癌患者,年龄>20岁,被纳入本系统评价和荟萃分析。结合13种效应大小,研究人员发现咖啡摄入与卵巢癌风险之间没有显著关联(RR:1.08; 95%CI:0.89,1.33)。此外,每天额外多喝一杯咖啡与卵巢癌风险增加略微相关(RR:1.02; 95%CI:0.99,1.05; P=0.21; I2=0.0%; 异质性P=0.68)。咖啡因摄入量、含咖啡因或不含咖啡因的咖啡摄入量与卵巢癌风险之间没有显著关联。

由此可见,研究人员发现咖啡因、不同类型的咖啡与卵巢癌风险之间没有显著关联。 

原始出处:

Asma Salari-Moghaddam,et al.Caffeine, type of coffee and risk of ovarian cancer: a dose-response meta-analysis of prospective studies.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2019-00637

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    2019-07-25 smallant2015
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    2020-04-02 sjq027
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    2020-03-19 achengzhao
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