Sci Rep:心脏手术后心脏康复期间的炎性细胞因子及其与术后房颤的关联

2020-05-26 xiangting MedSci原创

这项研究结果会影响术后预防性抗心律失常的治疗策略。

炎症与房颤(AF)具有相关性,但AF与急性术后期血清炎症细胞因子的关系仍不清楚。因此,这项研究旨在探讨心脏手术后心脏康复3周期间血浆细胞因子浓度是如何变化的,并将术后房颤(POAF)和永久性房颤患者与无房颤患者(NoAF组)进行了比较。

研究招募了100名连续性患者和40名健康志愿者作为对照。心脏康复开始时,术后11天,NoAF、POAF和永久性AF患者MPO、PTX3、ADAM17、sST2、IL-25和IL-33的血清水平显著升高,而TNFα和IL-37水平则明显低于健康志愿者。康复后,大多数细胞因子都趋于正常化。POAF患者(占总数的35%)比NoAF患者的体重指数高,并且腹型肥胖更常见,但一般特征和危险因素相似。然而,POAF患者的ADAM-17和IL-25始终低于NoAF患者,这表明IL-25和ADAM 17对发生POAF具有保护作用。

这项研究结果会影响术后预防性抗心律失常的治疗策略。

原始出处:

Vittorio Racca. Inflammatory Cytokines During Cardiac Rehabilitation After Heart Surgery and Their Association to Postoperative Atrial Fibrillation. Sci Rep. 25 May 2020.

 

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    2020-05-26 心介

    房颤,临床上碰到很多哦

    0

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