Chest:呼吸系统疾病和肺功能低下是痴呆的危险因素

2020-01-15 xing.T MedSci原创

由此可见,肺功能较差的个体患痴呆症的风险增加。尚不清楚肺功能不良与痴呆之间的关联程度如何。

除影响大脑的氧气供应外,肺功能是人体一生中多次遭受袭击的标志(包括吸烟、疾病和社会经济剥夺)。近日,呼吸领域权威杂志chest上发表了一篇研究文章,在对现有纵向研究的荟萃分析中,研究人员评估了以下假设:较低的肺功能和呼吸系统疾病与痴呆的风险增加有关。

研究人员对PubMed进行了检索,时间截至2019年4月1日,确定了相关的纵向研究进行系统评价,并在可能的情况下将结果汇总到随机效应的荟萃分析中。

研究人员确定了11项关于肺功能与以后痴呆症风险相关的研究,以及11项关于呼吸系统疾病与痴呆之间相关性的研究(包括一项对两者进行评估的研究)。一秒用力呼气量(FEV1)最低四分位数与最高四分位数相比,痴呆症风险增加了1.4倍(1.46,95%CI为0.77-2.75)(总的N=62209,两项研究)。FEV1降低一个标准差与痴呆症风险增加28%有关(1.28,95%CI为1.03-1.60;总的N=67505;六项研究)。呼吸系统疾病也与痴呆症风险增加有相似程度的关联(1.54,1.30-1.81,总的N=288641,11项研究)。

由此可见,肺功能较差的个体患痴呆症的风险增加。尚不清楚肺功能不良与痴呆之间的关联程度如何。

原始出处:

Tom C. Russ,et al.Respiratory disease and lower pulmonary function as risk factors for dementia: a systematic review with meta-analysis.chest.2020.https://journal.chestnet.org/article/S0012-3692(20)30009-X/fulltext

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    2020-08-19 Smile2680
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    2020-01-15 junJUN

    老年人痴呆何药可用??

    0

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