Heart:女性和男性左心室舒张功能纵向变化的危险因素

2019-04-03 xing.T 网络

由此可见,男性吸烟和男性代谢因素(糖尿病和体重指数)与LVDF参数的纵向变化之间存在较密切的有害关联。HDL与其之间的良好关联主要在女性中观察到。该研究首次评估了女性和男性持续LVDF参数随时间变化相关的危险因素,并为进一步的医学研究提供了新的假设。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究旨在评估社区居住女性和男性在11年内左心室舒张功能(LVDF)参数及其相关危险因素的变化。

在11年的随访期间,研究人员对前瞻性人群鹿特丹研究中的870名女性和630名男性(年龄67±3岁)进行了三次超声心动图检查,并使用线性混合效应模型(LMM)将六个连续LVDF参数的变化与血管危险因素相关联。

在女性中,吸烟与减速时间(DT)的有害纵向变化相关(β(β):7.73; 95%CI 2.56至12.9),并且高密度脂蛋白胆固醇与室间隔e'(β:0.37;95%CI为0.13至0.62)和E/e'比(β:-0.46; 95%CI为-0.84至-0.08)的改善有关。在男性中,糖尿病与A波(β:3.83; 95%CI为0.06至7.60)、室间隔e'(β:-0.40; 95%CI为-0.70至-0.09)和E/e'比值(β:0.60; 95%CI为0.14-1.06)的有害纵向变化有关,并且体重指数与A波(β:1.25; 95%CI为0.84-1.66)、E/A比(β:-0.007; 95%CI为-0.01至-0.003)、DT(β:0.86; 95%CI为0.017至1.71)和E/e'比(β:0.12; 95%CI为0.06至0.19)有害的纵向变化相关。

由此可见,男性吸烟和男性代谢因素(糖尿病和体重指数)与LVDF参数的纵向变化之间存在较密切的有害关联。HDL与其之间的良好关联主要在女性中观察到。该研究首次评估了女性和男性持续LVDF参数随时间变化相关的危险因素,并为进一步的医学研究提供了新的假设。

原始出处:

Oscar L Rueda-Ochoa.et al.Risk factors for longitudinal changes in left ventricular diastolic function among women and men.Heart.2019.http://dx.doi.org/10.1136/heartjnl-2018-314487

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    2019-06-28 yahu
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    2019-04-05 zhaojie88
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    2019-04-05 slcumt

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