Neurology:膳食中黄酮醇摄入量与阿尔茨海默症的风险

2020-01-31 xing.T MedSci原创

由此可见,饮食中黄酮醇的摄入量增加可能会降低患阿尔茨海默氏痴呆症的风险。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,该研究旨在明确黄酮醇饮食摄入量是否与阿尔茨海默氏痴呆症有关。

这项研究是在记忆和衰老项目(MAP)的921名参与者中进行的、基于社区的前瞻性队列研究。参加者使用经过验证的食物频率调查问卷完成年度神经系统评估和饮食评估。

在分析样本中最初没有痴呆的921名MAP参与者中,有220名参与者发展为阿尔茨海默氏痴呆。样本的平均年龄为81.2岁(SD为7.2),其中大多数(n=691,75%)是女性。总黄酮醇摄入量最高的参与者受教育程度更高,并且身体和认知活动参与程度更高。在Cox比例风险模型中,根据年龄、性别、受教育程度、APOEɛ4以及认知和身体活动参与程度进行调整后,饮食中黄酮醇的摄入与阿尔茨海默氏症发病呈反相关。第5个与第1个五分位数的风险比(HRs)如下:总黄酮含量为0.52(95%置信区间[CI]为0.33-0.84);山萘酚的浓度为0.49(95%CI为0.31-0.77);杨梅素为0.62(95%CI为0.4-0.97);对于异鼠李素为0.62(95%CI为0.39-0.98)。槲皮素与阿尔茨海默氏痴呆无关(HR为0.69;95%CI为0.43-1.09)。

由此可见,饮食中黄酮醇的摄入量增加可能会降低患阿尔茨海默氏痴呆症的风险。
 
原始出处:

Thomas M. Holland,et al.Dietary flavonols and risk of Alzheimer dementia.Neurology.2020.https://doi.org/10.1212/WNL.0000000000008981

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    2020-11-22 yinhl1978
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    2020-10-14 lmm397
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    2020-08-08 fengyi821
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    2020-02-02 heli0118
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