Hypertension:血压升高的年轻人存在亚临床收缩和舒张功能障碍

2020-05-06 MedSci原创 MedSci原创

血压和脂肪量是左心室收缩和舒张功能的具有统计学显著性的决定因素。即使在低于目前定义的高血压范围的BP水平,也可以检测到左心室收缩和舒张功能的亚临床变化。

高血压与成人心血管事件有关。在左室射血分数降低和心血管事件发生之前,已发现左心室应变和舒张功能的亚临床改变。近日,高血压领域权威杂志Hypertension上发表了一篇研究文章,研究人员旨在探究血压(BP)对年轻人心室功能的影响。

研究人员对346位年龄段为11至19岁的参与者进行了生命体征和实验室检查,并将他们的BP分为低风险(N=144;收缩压<75%)、中等风险(N=83;收缩压为80-90% )和高风险(N=119;收缩压≥90%)。受试者进行了超声心动图检查以评估左心室张力和舒张功能。研究人员通过ANOVA分析了各组之间的差异,并构建一般线性模型以确定收缩和舒张功能的独立预测因子。

与低风险组相比,中等风险和高风险参与者具有更高的体脂率,更多的不良代谢实验室检查结果(较低的高密度脂蛋白(HLD),更高的血糖和更高的胰岛素水平)。中等风险和高风险参与者的左心室射血分数和总体纵向应变峰值明显低于低风险组(均P≤0.05)。高风险组的E/e'比高风险组和中等风险组要高,而高风险组的e/a'比低风险组要低(P≤0.05)。

由此可见,血压和脂肪量是左心室收缩和舒张功能的具有统计学显著性的决定因素。即使在低于目前定义的高血压范围的BP水平,也可以检测到左心室收缩和舒张功能的亚临床变化。

原始出处:

Andrew H. Tran,et al.Subclinical Systolic and Diastolic Dysfunction Is Evident in Youth With Elevated Blood Pressure.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14682

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    2021-03-09 yahu
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    2020-05-06 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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