Alzheimer Dementia:长期睡眠不好,容易变“傻”

2021-06-29 Freeman MedSci原创

长期睡眠不好,容易变“傻”

目前,世界人口的中位年龄正在迅速上升。在美国,≥65岁的人口比例预计将从2000年的12.4%增长到2030年的19.6%。老年人与睡眠问题有关;事实上,超过一半的65岁以上的成年人报告至少有一种睡眠问题。

老年人的睡眠质量差与神经认知能力下降和痴呆症的发生有关。有关长期失眠的老年人的文献进一步表明,认知障碍的发生率很高,特别是在执行功能的测量方面。睡眠质量差可以预测在随访1年时,老年人的记忆和整体认知功能的下降。在最近的荟萃分析中,睡眠呼吸紊乱(SDB)、失眠和睡眠时间(SD)与阿尔茨海默病(AD)的风险增加有关。鉴于神经认知功能是预测老年人功能能力和生活质量的最重要因素,揭示与睡眠相关的神经认知功能下降的细微差别,对高危人群制定有针对性的干预措施是至关重要的。

老年人SDB和睡眠不足的常见相关因素包括代谢综合征(MetS)及其一些组成部分(即肥胖、高血压和糖尿病)。与非西班牙裔白人相比,西班牙裔/拉美裔患MetS的风险明显较高,患阿尔茨海默氏病和相关痴呆症(ADRD)的风险为4倍。

纵向研究也表明,失眠和SDB的症状可预测3年后的MetS事件。在西班牙裔/拉美裔成年人的不同队列中,短SD和白天打盹与肥胖之间有很强的关联。MetS是神经认知能力下降的一个强有力的预测因素,因此,研究由MetS改变的影响认知的睡眠特征是很重要的。

在年龄大于65岁的西班牙裔/拉美裔成年人中,MetS和肥胖的发生率较高。目前,直接研究睡眠措施预测不同年龄和性别组的神经认知能力下降的代谢途径的研究很少,特别是在脆弱的西班牙裔/拉美裔参与者中。

藉此,迈阿密大学的Sonya S. Kaur等人,研究了MetS和肥胖对不同年龄和性别组的西班牙裔/拉美裔成年人的睡眠表型与神经认知功能障碍和衰退之间关系的影响修饰。

暴露因素是基线SDB(呼吸事件指数≥15),困倦(Epworth困倦量表≥10),SD(<6小时,6-9小时,≥9小时),临床结局是7年后的认知减退(ND)。

他们发现,平均年龄为56.0岁,54.8%为女性。肥胖改变了最年长年龄组的SDB/SD和ND在记忆(F = 21.49, P < 0.001)和整体认知(F = 9.14, P < 0.001)方面的关联。

没有MetS的妇女在合并长睡眠/SDB的情况下,表现出最明显的整体认知下降(F = 3.07,P = 0.010)。

这个研究的重要意义在于:发现了在肥胖的老年人中,合并SDB/长睡眠与记忆、整体认知的下降之间的关系最明显。在女性中,MetS状态改变了长睡眠/SDB和整体认知下降之间的联系。

原文出处:
Kaur SS, Tarraf W, Wu B, Gonzalez KA, Daviglus M, Shah N, Sotres-Alvarez D, Gallo LC, Wohlgemuth W, Redline S, Gonzalez HM, Ramos AR. Modifying pathways by age and sex for the association between combined sleep disordered breathing and long sleep duration with neurocognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12361. Epub ahead of print. PMID: 34032354.

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    2021-06-29 ms4000000486455823

    学习

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    2021-06-29 ms3000001123359578

    学习

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    2021-06-29 13220084f6m

    学习了!

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    2021-06-29 言西早

    改善睡眠质量

    0

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    2021-06-29 学医无涯

    过犹不及!

    0

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牙周炎,或提示痴呆可能性

Neurology:一型糖尿病的老年人,痴呆风险更高

一型糖尿病的老年人,痴呆风险更高

Alzheimers Dementia:痴呆者,更容易患新冠,且和年龄无关

痴呆者,更容易患新冠,且和年龄无关

JECH:计算器竟然可以预测患痴呆症的风险!

计算器使 55 岁及以上的人能够更好地了解他们的大脑健康状况以及他们未来五年内被诊断出患有痴呆症的风险

Alzheimer Dementia-注意:痴呆确诊后,次年自杀率大大增加

注意-痴呆确诊后,次年自杀率大大增加

Alzheimers Dementia: 注意:肚子越大,越容易痴呆!

小心:肚子越大,越容易痴呆!