Eur Heart J:高甘油三酯会增加动脉粥样硬化性心血管病患者的风险

2020-01-06 不详 MedSci原创

REDUCE-IT临床试验结果显示乙醇酸盐可以改善动脉粥样硬化性心血管病(ASCVD)伴高甘油三酯血症患者的预后,在患有ASCVD的人群中,本研究试图量化与高甘油三酯血症相关的ASCVD事件。在ASCVD的患者中,本研究探究了甘油三酯(TG)和ASCVD事件(首次出现心肌梗死、不稳定心绞痛、中风或短暂缺血发作、冠状动脉血运重建或心血管死亡)之间的相关性。TG 135-499mg/dL(1.52-5

REDUCE-IT临床试验结果显示乙醇酸盐可以改善动脉粥样硬化性心血管病(ASCVD)伴高甘油三酯血症患者的预后,在患有ASCVD的人群中,本研究试图量化与高甘油三酯血症相关的ASCVD事件。

在ASCVD的患者中,本研究探究了甘油三酯(TG)和ASCVD事件(首次出现心肌梗死、不稳定心绞痛、中风或短暂缺血发作、冠状动脉血运重建或心血管死亡)之间的相关性。TG 135-499mg/dL(1.52-5.63mmol/L)和低密度脂蛋白胆固醇(LDLc)41-100mg/dL(1.06-2.59mmol/L)的ASCVD患者可能会获益于乙醇酸盐。最终共纳入分析了196717名ASCVD患者,平均年龄为69岁,女性占30%,经过平均2.9年时间的随访,共有24097例ASCVD事件发生,增高的TG水平与ASCVD事件的发生相关,有25%的ASCVD患者存在高甘油三酯血症,这些患者的人口统计学特征与REDUCE-IT临床试验中的相似。

研究结果显示,在动脉粥样硬化性心血管病患者中,高甘油三酯血症是常见的,且与ASCVD事件的发生相关。有多达四分之一的ASCVD患者可能需要治疗。

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    2020-01-08 zhaojie88
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    2020-01-08 slcumt

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