JAHA:肠道菌群与血压之间的关联

2020-07-22 MedSci原创 MedSci原创

尽管总体肠道微生物分类组成与BP之间的关联较弱,但高血压患者表现出几个菌属的改变。该研究证明了某些乳杆菌物种与钠摄入量和血压之间存在强烈的负相关性,强调了进行实验性研究的必要性。

几项小型动物研究表明,肠道菌群与血压(BP)之间存在联系。但是,人类研究的结果仍然很少且相互矛盾。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在通过一个大型、代表性、表型明确的人群样本阐明肠道元基因组和BP之间的多变量调整关联。研究人员进行了重点分析,以评估先前报道的钠摄入量与乳酸杆菌丰度之间以及乳酸杆菌丰度与血压之间的负相关关系。

研究人员分析了6953名年龄在25至74岁之间的芬兰人(平均年龄为49.2±12.9岁;54.9%为女性)。参与者接受了健康检查,包括血压测量,粪便收集和24小时尿液采样(N=829),并使用鸟枪基因组测序分析肠道菌群。

在经过年龄和性别调整的模型中,分类学组成的α(样本内)和β(样本间)多样性与BP密切相关(大多数情况下P<0.001)。在多变量调整模型中,β多样性仅与舒张压相关(P=0.032)。但是,研究人员观察到BP与45个微生物属之间存在显著的、主要是正相关的关系(P<0.05),其中27个属于厚壁菌门。有趣的是,研究人员发现19种不同的乳酸杆菌与BP之间大多呈负相关(P<0.05)。其中,已知的益生菌干酪乳杆菌含量较高与平均动脉压降低和饮食钠摄入量降低有关(两者均有P<0.001)。

由此可见,尽管总体肠道微生物分类组成与BP之间的关联较弱,但高血压患者表现出几个菌属的改变。该研究证明了某些乳杆菌物种与钠摄入量和血压之间存在强烈的负相关性,强调了进行实验性研究的必要性。

原始出处:

Joonatan Palmu.et al.Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.016641

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    2020-07-24 zhaohui6731
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    2020-07-23 1240394fm61暂无昵称

    如何想到的

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1268296, encodeId=78d41268296a4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392402, encodeId=0f9f139240259, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804073, encodeId=a30d8040e3ce, content=如何想到的, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:31 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804072, encodeId=7a408040e2b6, content=新发现, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:15 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804006, encodeId=4754804006b3, content=新角度, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c01c5209406, createdName=14757fdfm46暂无昵称, createdTime=Wed Jul 22 21:24:22 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803986, encodeId=21df80398666, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>与高血压的关系实在有点不靠谱了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 22 20:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=)]
    2020-07-23 1240394fm61暂无昵称

    新发现

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1268296, encodeId=78d41268296a4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392402, encodeId=0f9f139240259, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804073, encodeId=a30d8040e3ce, content=如何想到的, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:31 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804072, encodeId=7a408040e2b6, content=新发现, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:15 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804006, encodeId=4754804006b3, content=新角度, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c01c5209406, createdName=14757fdfm46暂无昵称, createdTime=Wed Jul 22 21:24:22 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803986, encodeId=21df80398666, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>与高血压的关系实在有点不靠谱了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 22 20:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=)]
    2020-07-22 14757fdfm46暂无昵称

    新角度

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1268296, encodeId=78d41268296a4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392402, encodeId=0f9f139240259, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Jul 24 04:23:21 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804073, encodeId=a30d8040e3ce, content=如何想到的, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:31 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804072, encodeId=7a408040e2b6, content=新发现, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 23 09:42:15 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804006, encodeId=4754804006b3, content=新角度, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c01c5209406, createdName=14757fdfm46暂无昵称, createdTime=Wed Jul 22 21:24:22 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803986, encodeId=21df80398666, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>与高血压的关系实在有点不靠谱了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 22 20:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=)]
    2020-07-22 lovetcm

    #肠道菌群#与高血压的关系实在有点不靠谱了。

    0

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