Pharmacotherapy:塞来昔布治疗骨关节炎患者健康相关生活质量的功能状态评估

2020-05-11 MedSci原创 MedSci原创

本研究旨在评估塞来昔布与安慰剂和萘普生相比,治疗膝骨关节炎症状和体征的患者的功能状态。

本研究旨在评估塞来昔布与安慰剂和萘普生相比,治疗膝骨关节炎症状和体征的患者的功能状态。

 

采用前瞻性、随机、双盲、平行组设计,为期12周。在美国和加拿大的71个站点进行了多中心研究。 1440名活动性膝关节骨性关节炎患者处于耀斑状态。将患者随机分配到五个治疗组之一:安慰剂;塞来昔布50 mg /天,100 mg /天和200 mg /天;和萘普生500毫克/天两次。使用西安大略省和麦克马斯特大学的骨关节炎指数来衡量功能状态。

 

结果显示,在治疗期结束时,四个积极治疗组的患者的功能状态明显优于接受安慰剂的患者。每天两次接受100 mg塞来昔布治疗的患者的疼痛评分明显好于安慰剂和萘普生治疗的患者。

 

综上所述,该研究结果表明,塞来昔布在改善骨关节炎患者的功能状态方面优于安慰剂,与萘普生相当。

 

原始出处:

 

S Z ZhaoJ I McMillen, et al., Evaluation of the Functional Status Aspects of Health-Related Quality of Life of Patients With Osteoarthritis Treated With Celecoxib. Pharmacotherapy. 1999 Nov;19(11):1269-78. doi: 10.1592/phco.19.16.1269.30879.

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    2020-08-09 yb6560
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    2020-10-15 lisa438
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    2020-10-22 jj000001
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1996357, encodeId=e73b199635e8c, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Aug 09 03:43:44 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026674, encodeId=b6a320266e4da, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Thu Oct 15 09:43:44 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787668, encodeId=a8971e8766854, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu Oct 22 16:43:44 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908591, encodeId=757119085915a, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Oct 17 01:43:44 CST 2020, time=2020-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739013, encodeId=ce4e1e390130f, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Wed Feb 03 03:43:44 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266176, encodeId=e2be12661e6ae, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed May 13 06:43:44 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283834, encodeId=22bc1283834a9, content=<a href='/topic/show?id=082842228d3' target=_blank style='color:#2F92EE;'>#塞来昔布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42228, encryptionId=082842228d3, topicName=塞来昔布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Wed May 13 06:43:44 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522205, encodeId=c72b15222058c, content=<a href='/topic/show?id=d08e2e894e7' target=_blank style='color:#2F92EE;'>#健康相关生活质量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27894, encryptionId=d08e2e894e7, topicName=健康相关生活质量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0411427202, createdName=yilong5287546, createdTime=Wed May 13 06:43:44 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622934, encodeId=3c4316229346e, content=<a href='/topic/show?id=abff3292584' target=_blank style='color:#2F92EE;'>#功能状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32925, encryptionId=abff3292584, topicName=功能状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 13 06:43:44 CST 2020, time=2020-05-13, status=1, ipAttribution=)]
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    2020-05-13 lmm397
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