Eur Heart J:睡眠方式、遗传易感性与心血管疾病发病率

2019-12-20 xing.T MedSci原创

由此可见,在这项大型前瞻性研究中,健康的睡眠模式与低、中或高遗传风险参与者的CVD、CHD和卒中风险降低相关。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,这项旨在量化睡眠行为和遗传易感性与心血管疾病(CVD)发生率之间的关系。

该研究纳入了385292名来自英国生物库且最初没有CVD的参与者。研究人员根据五个睡眠因素重新建立了健康的睡眠评分,并将低风险组定义为:早期表型、每天睡眠7-8 h、从未/很少失眠、不打呼、白天无频繁嗜睡。研究人员计算了冠心病(CHD)或卒中的加权遗传风险评分。

在平均8.5年的随访期间,研究人员记录了7280例CVD事件,包括4667例CHD和2650例卒中病例。与睡眠评分为0-1的参与者相比,得分为5的参与者CVD、CHD和卒中的患病风险分别降低了35%(19-48%)、34%(22-44%)和34%(25-42%)。该队列中近10%的心血管事件可归因于不良的睡眠方式。睡眠质量差、遗传风险高的参与者表现出最高的CHD和卒中风险。

由此可见,在这项大型前瞻性研究中,健康的睡眠模式与低、中或高遗传风险参与者的CVD、CHD和卒中风险降低相关。   

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GetPortalCommentsPageByObjectIdResponse(id=377224, encodeId=dc8f3e7224a0, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 21 00:19:05 CST 2019, time=2019-12-21, status=1, ipAttribution=)]
    2019-12-22 zhaojie88
  5. 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  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=377224, encodeId=dc8f3e7224a0, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 21 00:19:05 CST 2019, time=2019-12-21, status=1, ipAttribution=)]
  8. 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createdName=july_975, createdTime=Fri Aug 07 02:47:00 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798861, encodeId=6aac1e98861a0, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Sat Sep 26 12:47:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357338, encodeId=d2a5135e3384f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 22 12:47:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454713, encodeId=3bbd1454e1310, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Sun Dec 22 12:47:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460566, encodeId=9de914605665f, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, 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GetPortalCommentsPageByObjectIdResponse(id=377224, encodeId=dc8f3e7224a0, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 21 00:19:05 CST 2019, time=2019-12-21, status=1, ipAttribution=)]
    2019-12-22 slcumt
  9. 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    2019-12-21 天地飞扬

    学习

    0

  10. 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encodeId=89af1563188e6, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Dec 22 12:47:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377262, encodeId=8da03e726209, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Dec 21 22:53:53 CST 2019, time=2019-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377224, encodeId=dc8f3e7224a0, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 21 00:19:05 CST 2019, time=2019-12-21, status=1, ipAttribution=)]
    2019-12-21 飛歌

    学习了很有用不錯

    0