Stroke:左侧大脑半球脑卒中后语言功能障碍的恢复与右侧大脑半球结构有何关系?

2020-07-09 shaosai MedSci原创

脑卒中是美国功能障碍最主要的原因,失语是左侧大脑半球脑卒中常见的后遗症。功能成像和脑刺激研究显示右侧大脑半球结构是失语功能恢复的决定性因素,但来源于DTI相关研究结果并不多见。本研究旨在评估同源语言通

背景与目的

卒中是美国功能障碍最主要的原因,失语是左侧大脑半球脑卒中常见的后遗症。功能成像和脑刺激研究显示右侧大脑半球结构是失语功能恢复的决定性因素,但来源于DTI相关研究结果并不多见。本研究旨在评估同源语言通路在左侧大脑半球脑卒中后命名功能恢复的作用。


方法

本研究纳入了左侧大脑半球脑卒中并出现失语的患者,利用Boston命名量表和DTI评估急性期和慢性期命名功能情况。利用DTI评价右侧弓状束、额斜束。利用Wilcoxon等级总和检验评价结构偏侧性模式,部分spearman相关性或多元广义线性模型炎症右侧弓状束和额斜束在命名恢复中的作用。对多重比较结果进行校正。

结果

平均上,左侧语言通路的结构完整性损坏要比左侧同源通路严重,在慢性期具有右侧倾向的偏侧性变化。回归或相关性分析显示右侧弓状束纤维束完整性越好与命名功能恢复较差具有相关性。

结论

本研究显示语言通路的右侧同源通路的保留与左侧半球脑卒中后命名功能恢复较差具有相关性,这也与前期研究中语言从那个对左侧半球结构的依赖性与较好的语言功能恢复具有相关性。

原始出处:

Keser Z, Sebastian R, Hasan KM et al.Right Hemispheric Homologous Language Pathways Negatively Predicts Poststroke Naming Recovery.DOI:10.1161/STROKEAHA.119.028293

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    2021-12-27 sallyren

    很有启发

    0

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    2020-07-11 yangjxjc
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    2020-07-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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