Int Arch Allergy Immunol:过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎成人患者鼻刷的基因表达分析

2020-11-29 AlexYang MedSci原创

在过敏性鼻炎患者中,上皮基因的表达已通过基因芯片进行评估。然而,在非过敏性鼻炎和疑似过敏性鼻炎患者中,他们报告了过敏原相关鼻部症状但呈现阴性过敏测试结果,其基因表达情况尚不清楚。

在过敏性鼻炎患者中,上皮基因的表达已通过基因芯片进行评估。然而,在非过敏性鼻炎和疑似过敏性鼻炎患者中,他们报告了过敏原相关鼻部症状但呈现阴性过敏测试结果,其基因表达情况尚不清楚。

最近,有研究人员观察和比较了过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者的上皮基因表达情况。研究人员从健康对照和患者中收集了鼻刷。研究结果发现,12个基因在目前对多种过敏原过敏的成人过敏性鼻炎患者中上调,其中10个基因在疑似过敏性鼻炎组和非过敏性鼻炎组中也有所增加。TFF3和ITLN1在过敏性鼻炎和疑似过敏性鼻炎中表达增加,但在非过敏性鼻炎中没有增加。过敏性鼻炎组和非过敏性鼻炎组之间有3个基因的表达不同,分别为CST1、TFF3和ITLN1。在过敏性鼻炎患者中,上述所有12个基因在季节过敏组和常年过敏组中全部上调;其中的9个基因在混合组中也上调。在疑似过敏性鼻炎患者中,常年过敏组的12个基因全部上调,季节组有8个基因上调,混合组只有5个基因上调。另外,这些基因的表达与病程和血清总IgE均无关联。在疑似过敏性鼻炎组中,GCNT3与鼻腔涂片嗜酸粒细胞的等级呈正相关,还发现不同基因与不同鼻炎组的疾病严重程度相关。

最后,研究人员指出,过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。另外,了解不同类型鼻炎的机制可能有助于鼻炎的诊断和治疗。

原始出处:

Min Wang , Wenyu She , Jun Yang et al. Gene Expression Analysis by Real-Time PCR in Nasal Brushings of Adult Patients with Allergic Rhinitis, Suspected Allergic Rhinitis, and Nonallergic Rhinitis. Int Arch Allergy Immunol. Nov 2020

 

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target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Dec 01 12:38:23 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903455, encodeId=10509034556a, content=过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 30 08:15:00 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903425, encodeId=fab390342509, content=诊断第一步,疗效是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Mon Nov 30 00:28:47 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903390, encodeId=4c6d903390e9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc871736062, createdName=1defb793m85(暂无匿称), createdTime=Sun Nov 29 22:26:40 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-12-05 MMCyuan

    学习

    0

  5. 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target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Dec 01 12:38:23 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903455, encodeId=10509034556a, content=过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 30 08:15:00 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903425, encodeId=fab390342509, content=诊断第一步,疗效是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Mon Nov 30 00:28:47 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903390, encodeId=4c6d903390e9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc871736062, createdName=1defb793m85(暂无匿称), createdTime=Sun Nov 29 22:26:40 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-12-01 膀胱癌
  6. 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target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Dec 01 12:38:23 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903455, encodeId=10509034556a, content=过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  7. 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target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Dec 01 12:38:23 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903455, encodeId=10509034556a, content=过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc871736062, createdName=1defb793m85(暂无匿称), createdTime=Sun Nov 29 22:26:40 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-11-30 Oranhyg

    过敏性鼻炎、疑似过敏性鼻炎和非过敏性鼻炎患者在上皮基因表达方面有很多相似之处,大部分基因与Th2炎症有关。CST1、TFF3和ITLN1可能具有区分过敏性鼻炎和非过敏性鼻炎的潜力。

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc871736062, createdName=1defb793m85(暂无匿称), createdTime=Sun Nov 29 22:26:40 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-11-30 爱读书的大丽子

    诊断第一步,疗效是关键

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc871736062, createdName=1defb793m85(暂无匿称), createdTime=Sun Nov 29 22:26:40 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-11-29 1defb793m85(暂无匿称)

    学习了

    0

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