JCEM:孕期维生素B12低水平导致肥胖的机制研究

2017-09-29 MedSci MedSci原创

孕期维生素B12(B12)水平较低与母亲肥胖、胰岛素抵抗(IR)和妊娠期糖尿病(GDM)有关。维生素B12是一碳代谢的一个关键因素。

背景:孕期维生素B12(B12)水平较低与母亲肥胖、胰岛素抵抗(IR)和妊娠期糖尿病(GDM)有关。维生素B12是一碳代谢的一个关键因素。

目的:本研究旨在根据研究人员的推测,探讨在一个不良的代谢表型中,B12是通过改变循环miRNA的表观遗传调控脂肪细胞分化过程及结果的。

方法:根据不同的B12浓度,使人前脂肪细胞系(Chub-S7)不同:控制组(500nM),低B12组(0.15nM)和无B12组(0nM)。分娩时采集母体血液样本(n=91)和皮下脂肪组织(n=42)。研究人员测定了血清维生素B12、叶酸、血脂、血浆一碳代谢、miR性能分析、miR表达和基因表达。

结果:体外模型显示,B12缺乏的条件下脂肪组织积累更多的脂肪,有较高的甘油三酯水平和脂肪生成和脂肪合成基因的表达增加。红外阵列筛选发现133miR表达的多样性(调整后的P<0.05),这涉及多个代谢途径。在脂肪细胞的miR表达中观察到了12个miR与脂肪细胞分化和功能的相关改变相关。

在维生素B12水平较低的孕妇中验证这些数据发现,SAT中脂肪/脂质合成基因和相关miR的表达增加,循环中12个miR中的11个的表达水平增加,都得到了证明。在调整了其他可能的混杂因素后,多元回归分析显示BMI和B12独立相关(β:-0.264;95% CI:-0.469,-0.058;P = 0.013),B12是由四个循环miR靶向的PPARγ和IR所介导。

结论:孕期维生素B12低水平能改变脂肪中的循环miR,而miR能调控脂肪导致肥胖和IR表型。

原始出处:

Adaikalakoteswari A, Vatish M,et al.Low vitamin B12 in pregnancy is associated with adipose derived circulating miRs targeting PPARγ and insulin resistance.J Clin Endocrinol Metab. 2017 Sep 5. doi: 10.1210/jc.2017-01155. [Epub ahead of print]

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1777672, encodeId=74ef1e77672da, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Nov 01 13:39:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063054, encodeId=15c8206305412, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Jan 29 10:39:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056167, encodeId=c8d3205616e1c, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Dec 10 05:39:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414878, encodeId=b01514148e8d8, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508527, encodeId=c592150852e33, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-11-01 smallant2015
  2. [GetPortalCommentsPageByObjectIdResponse(id=1777672, encodeId=74ef1e77672da, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Nov 01 13:39:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063054, encodeId=15c8206305412, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Jan 29 10:39:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056167, encodeId=c8d3205616e1c, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Dec 10 05:39:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414878, encodeId=b01514148e8d8, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508527, encodeId=c592150852e33, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2018-01-29 achengzhao
  3. [GetPortalCommentsPageByObjectIdResponse(id=1777672, encodeId=74ef1e77672da, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Nov 01 13:39:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063054, encodeId=15c8206305412, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Jan 29 10:39:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056167, encodeId=c8d3205616e1c, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Dec 10 05:39:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414878, encodeId=b01514148e8d8, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508527, encodeId=c592150852e33, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1777672, encodeId=74ef1e77672da, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Nov 01 13:39:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063054, encodeId=15c8206305412, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Jan 29 10:39:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056167, encodeId=c8d3205616e1c, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Dec 10 05:39:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414878, encodeId=b01514148e8d8, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508527, encodeId=c592150852e33, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1777672, encodeId=74ef1e77672da, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Nov 01 13:39:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063054, encodeId=15c8206305412, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Jan 29 10:39:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056167, encodeId=c8d3205616e1c, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Dec 10 05:39:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414878, encodeId=b01514148e8d8, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508527, encodeId=c592150852e33, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Sun Oct 01 14:39:00 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 马龙

相关资讯

五个医生做麻醉 东营260斤超重孕妇剖宫产子

260斤超重孕妇剖宫产,平时打麻药只需要一个医生,结果这名孕妇仅打麻药就用了五个医生。近日,东营市人民医院手术室迎来了一位“重量级嘉宾”。29岁的准妈妈小兰(化名)身高约160cm,体重130Kg。经过医生们的通力合作和努力,成功为小兰实施麻醉并剖腹产,最终小兰喜获一个约九斤重的大胖儿子。

新研究认为流感疫苗与流产存在关联引质疑

近日,网络头条充斥着将流感疫苗与流产相关联的消息。美国《华盛顿邮报》称,一项新研究中“潜在关联的暗示”可能导致对疫苗安全性的质疑。该文章作者之一是威斯康星州马斯菲尔德研究所广受尊敬的流感研究者Edward Belongia,他同时担任美国免疫接种问题咨询委员会主任。这项小规模研究发现,两年内接种含有一种特定病毒株流感疫苗的女性存在流产的几率略高一些,研究中充满了“可能”“或许”“或者会”等词汇。研

Eur radiol:孕妇发生急性阑尾炎,要不做个MRI检查?

妊娠急性阑尾炎严重威胁着孕妇、胎儿的生命安全,故应引起高度重视。孕妇患了阑尾炎后炎症容易扩散,细菌产生的毒素可通过血液影响胎儿,使胎儿缺氧,重者可致胎儿死亡。同时发炎的阑尾也可直接刺激子宫,引起子宫收缩,造成早产或流产。随着妊娠月数的增加,增大的子宫可压迫推移盲肠、阑尾及升结肠,使其血运出现障碍,蠕动减弱,粪便易于积存,故阑尾腔一旦发生梗阻,就不易自行缓解。本研究旨在评估对怀疑有急性阑尾炎的孕妇进

秋季,孕妇如何预防便秘

便秘是孕妇常发生的症状之一,秋季燥邪当季,气候干燥,容易损伤人体津液。而阴液损伤后容易诱发或加重便秘的症状。所以在秋季,孕妇更要注意调整饮食,来预防便秘的出现。

Lancet:I型糖尿病孕妇动态血糖监测可显著改善新生儿结局

研究认为,对于I型糖尿病孕产妇,有效性的动态血糖监测可显著改善新生儿结局

Hypertension:西地那非对孕妇血压及胎儿生长的荟萃分析!

西地那非是治疗胎儿生长受限(FGR)和先兆子痫的新方法。近期,一项发表在杂志Hypertension上的研究进行了系统的荟萃分析来评估西地那非的疗效。此项研究搜索确定了22项动物研究(小鼠、大鼠、兔、绵羊和豚鼠)以及2项人类随机对照试验。使用胎儿生长和母亲血压平均值差异和95%置信区间的数据进行汇总。对可能影响西地那非疗效的相关因素进行Meta回归分析,包括使用模型(健康怀孕与FGR /先兆子痫)