Nat Sci Sleep: 慢性失眠症患者海马/海马旁回和执行控制网络之间的功能连接存在性别差异

2022-06-29 影像小生 MedSci原创

在被诊断为CID的患者中,HIP/PHG和执行控制网络之间的脑连接存在性别差异

失眠是临床工作中出现的主要主诉,其特点是睡眠不满意,以及难以在夜间开始或维持睡眠。它伴随着痛苦和损害在白天的功能。2研究表明,约10% - 20%的人患有失眠症,约50%的人发展为慢性失眠症(CID)。此外,在2019年冠状病毒病大流行期间,失眠的患病率是原来的两倍和三倍。失眠症会带来大量的医疗保健和间接成本,因为它会对认知功能受损导致的精神障碍造成重大风险。流行病学、神经生物学和心理学的研究发现并表现出了失眠的性别差异,流行病学研究的一致结果表明,失眠在女性中大约是男性的1.5倍随着年龄的增长,女性患失眠症的风险比例也会增加,但男性没有。一些研究调查了睡眠障碍患者与性别差异相关的大脑机制。Dai等人在一项功能性神经影像学研究中也观察到,女性失眠患者双侧颞回的脑区域活动较高,而左侧边缘叶的脑区域活动较低然而,他们并没有探索失眠和性别对大脑区域活动的交互影响。基于我们之前的研究,我们观察到性别并不影响原发性失眠症患者的整体功能连接(FC)密度此外,在蓝斑功能网络中还观察到性别差异然而,到目前为止,性别差异如何影响失眠的神经病理机制仍不清楚。

最近Nature and Science of Sleep刊发了成都中医药大学针灸推拿系Lili Yang等的研究文章,旨在探讨性别对CID患者海马/海马旁回(HIP/PHG)功能网络的调节作用。

这项研究招募了110名被诊断为CID的患者(43名男性和67名女性)和60名匹配良好的睡眠对照组(GSC)(22名男性和38名女性)。这些参与者接受静息态功能磁共振成像扫描,之后使用2×2(诊断性别)方差分析来检测失眠和性别对HIP/PHG FC网络的主要和交互效应。

诊断对左海马功能连接网络的主效应

性别对海马功能网络的主效应。性别对左侧海马功能网络(位于右侧CbP)的主效应(A和B);性别对右侧海马功能网络(位于左侧DLPFC、右侧SMA、ITG和FFA)的主效应(C和D)。

1.虽然失眠对HIP FC网络主效应见于双侧小脑扁桃体、额上回和内侧眶额皮质,对双侧HIP和杏仁核的PHG FC网络也有影响。相反,性别对HIP FC网络的主效应见于右小脑后叶、背外侧前额叶皮层(DLPFC)和辅助运动区。

2.值得注意的是,失眠和性别在右侧HIP和背侧前扣带皮层之间的FCs,以及右侧PHG和DLPFC之间的FCs中观察到交互效应。

诊断性别对右侧海马功能连接网络(A)和右侧海马旁回功能连接网络(B)的交互效应。

3.女性CID患者右侧PHG和左侧DLPFC之间的FC与焦虑得分呈正相关。

在被诊断为CID的女性中,右侧PHG和左侧DLPFC之间的功能连接与焦虑症状呈正相关

该研究发现,在被诊断为CID的患者中,HIP/PHG和执行控制网络之间的脑连接存在性别差异,这些结果将最终扩展对性别在CID病理生理中发挥重要作用的认识。

原文出处

Yang L, Yu S, Zhang L, Peng W, Hu Y, Feng F, Yang J. Gender Differences in Hippocampal/Parahippocampal Functional Connectivity Network in Patients Diagnosed with Chronic Insomnia Disorder. Nat Sci Sleep. 2022;14:1175-1186
https://doi.org/10.2147/NSS.S355922

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1885851, encodeId=313a18858519a, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon May 01 01:38:09 CST 2023, time=2023-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299398, encodeId=40c01299398af, content=<a href='/topic/show?id=59d64429252' target=_blank style='color:#2F92EE;'>#失眠症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44292, encryptionId=59d64429252, topicName=失眠症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345071, encodeId=412a13450e169, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445808, encodeId=2001144580852, content=<a href='/topic/show?id=a343329413c' target=_blank style='color:#2F92EE;'>#功能连接#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32941, encryptionId=a343329413c, topicName=功能连接)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJciayulicXZn6VO5hXfUv98oceXTHpMayS6T4PrSPsgsN6Jt2kCyAo9tAQwf1jCiaw4y8lxZFBA5nJg/132, createdBy=5ddb5182578, createdName=showtest, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=)]
    2023-05-01 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1885851, encodeId=313a18858519a, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon May 01 01:38:09 CST 2023, time=2023-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299398, encodeId=40c01299398af, content=<a href='/topic/show?id=59d64429252' target=_blank style='color:#2F92EE;'>#失眠症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44292, encryptionId=59d64429252, topicName=失眠症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345071, encodeId=412a13450e169, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445808, encodeId=2001144580852, content=<a href='/topic/show?id=a343329413c' target=_blank style='color:#2F92EE;'>#功能连接#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32941, encryptionId=a343329413c, topicName=功能连接)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJciayulicXZn6VO5hXfUv98oceXTHpMayS6T4PrSPsgsN6Jt2kCyAo9tAQwf1jCiaw4y8lxZFBA5nJg/132, createdBy=5ddb5182578, createdName=showtest, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=)]
    2022-06-24 日月
  3. [GetPortalCommentsPageByObjectIdResponse(id=1885851, encodeId=313a18858519a, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon May 01 01:38:09 CST 2023, time=2023-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299398, encodeId=40c01299398af, content=<a href='/topic/show?id=59d64429252' target=_blank style='color:#2F92EE;'>#失眠症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44292, encryptionId=59d64429252, topicName=失眠症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345071, encodeId=412a13450e169, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445808, encodeId=2001144580852, content=<a href='/topic/show?id=a343329413c' target=_blank style='color:#2F92EE;'>#功能连接#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32941, encryptionId=a343329413c, topicName=功能连接)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJciayulicXZn6VO5hXfUv98oceXTHpMayS6T4PrSPsgsN6Jt2kCyAo9tAQwf1jCiaw4y8lxZFBA5nJg/132, createdBy=5ddb5182578, createdName=showtest, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1885851, encodeId=313a18858519a, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon May 01 01:38:09 CST 2023, time=2023-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299398, encodeId=40c01299398af, content=<a href='/topic/show?id=59d64429252' target=_blank style='color:#2F92EE;'>#失眠症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44292, encryptionId=59d64429252, topicName=失眠症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345071, encodeId=412a13450e169, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445808, encodeId=2001144580852, content=<a href='/topic/show?id=a343329413c' target=_blank style='color:#2F92EE;'>#功能连接#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32941, encryptionId=a343329413c, topicName=功能连接)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJciayulicXZn6VO5hXfUv98oceXTHpMayS6T4PrSPsgsN6Jt2kCyAo9tAQwf1jCiaw4y8lxZFBA5nJg/132, createdBy=5ddb5182578, createdName=showtest, createdTime=Fri Jun 24 11:38:09 CST 2022, time=2022-06-24, status=1, ipAttribution=)]

相关资讯

Alzheimer&Dementia:痴呆患病有明显性别差异,主要与这些因素有关!

痴呆症的负担不仅在地域上分布不均,而且在性别上也不均衡。

J Thorac Oncol:肺癌患者性别的生存差异以及预后因素对其影响

研究表明,性别相关的肺癌生存差异很大程度上是由已知的预后因素所决定的,这表明有机会探索治疗偏好、选择和可及性方面的性别差异。

Neurology:AAN会员年度薪酬调查:性别薪资差异在神经科医师中亦存在!

近日,1项回顾性的横向研究评估了神经科医生性别补偿差异的补偿和生产力调查数据。证明尽管调整了多个混杂变量,医生的报酬仍然存在差异。尽管公约等专业协会做出了努力,但仍存在持续的系统性问题和障碍。

JEADV:青年女性和男性特应性皮炎的患病率和特征

特应性皮炎(AD)是一种以反复瘙痒、湿疹和皮肤干燥为特征的炎症性皮肤病。研究结果表明,在各个年龄段发病率、IgE敏感率等方面AD在男性和女性之间存在差异。

Neurology:芬兰青年的心血管风险研究:持续高水平血清肌酐或与中年男性学习、记忆功能更佳相关!

血清肌酐通常用于评估肾功能,其升高会增加认知能力低下的风险。研究调查了中年时血清肌酐和认知表现之间的关系,发现在男性中,与低水平的血清肌酐相比,持续的高水平可能与中年时更好的记忆和学习功能有关。

新冠疫情下男男女女的差异有多大?

在应对疫情过程中,性别差异往往容易被忽视。比如,女性卫生用品一度成为抗疫一线医务人员被遗忘的刚需,她们的物资紧缺要比男性医务人员多出几样,但当有爱心人士向某地医疗机构捐赠这些物资时,居然有医院认为用不