Lancet Diabetes Endo:艾塞那肽不能作为I型糖尿病患者胰岛素治疗的辅助治疗手段

2020-03-03 MedSci MedSci原创

研究认为,醋酸艾塞那肽作为I型糖尿病患者胰岛素治疗的辅助治疗效果不理想

在II型糖尿病中,长效GLP-1受体激动剂通过促胰岛素和胰高血糖素的作用,降低空腹血糖,改善血糖控制。在I型糖尿病中,其作为胰岛素治疗的辅助治疗,疗效是限的。研究发现短效GLP-1受体激动剂可通过降低排空率该II型糖尿病患者餐后血糖波动。近日研究人员考察了短效GLP-1受体激动剂对I型糖尿病的疗效。

MAG1C研究中,18岁及以上、HbA 1c 59-88 mmol/mol(7.5-10.0%)且BMI大于22.0 kg/m 2的I型糖尿病患者,随机接受皮下注射10μg醋酸艾塞那肽(Byet ta)或安慰剂,每日三次,持续26周,作为常规胰岛素治疗的补充治疗。研究的主要终点为26周后HbA1c的组间差异。

108名患者参与研究其中,醋酸艾塞那肽组54名,安慰剂组54名,23名参与者停止治疗(醋酸艾塞那肽组17名,安慰剂组6名)。基线HbA1c校正平均值66.4 mmol/mol,26周后,醋酸艾塞那肽组的HbA 1c 变化为-3.2 mmol/mol,安慰剂组为-2.1 mmol/mol。醋酸艾塞那肽增加了自我报告的肠道不良事件(主要是恶心,37名醋酸艾塞那肽组患者中发生了48起事件, 9例安慰剂患者中发生了9起事件])。在醋酸艾塞那肽组中发生了两起严重的不良事件,在安慰剂组中发生了六起(没有一个被认为与研究药物有关)。

研究认为,醋酸艾塞那肽作为I型糖尿病患者胰岛素治疗的辅助治疗效果不理想。

原始出处:


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    2021-01-12 howi
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2020, time=2020-03-03, status=1, ipAttribution=)]
  5. 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2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514663, encodeId=817e151466353, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Thu Mar 05 10:34:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042993, encodeId=885110429930d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Mar 03 22:34:00 CST 2020, time=2020-03-03, status=1, ipAttribution=)]
    2020-10-25 baoya
  6. 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  7. 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  8. 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2020, time=2020-03-03, status=1, ipAttribution=)]
    2020-03-03 misszhang

    谢谢MedSci提供最新的资讯

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