Cell Death Dis:SKA3通过调节CDK2/P53磷酸化促进肝癌发生发展

2020-01-01 QQY MedSci原创

纺锤体及着丝粒相关复合物亚基3(SKA3)是纺锤体及着丝粒相关复合物的重要组成成分,对有丝分裂后期的精准进行至关重要。但目前SKA3与肝细胞癌(HCC)之间的关系还尚不清楚。研究人员采用GEO数据库(GSE62232,GSE45436,GSE6764和GSE36376)和TCGA数据库进行分析鉴定差异表达基因。通过CCK8细胞增殖毒性检测实验及平板克隆形成实验分析细胞的增殖能力,而通过划痕实验及小

纺锤体及着丝粒相关复合物亚基3(SKA3)是纺锤体及着丝粒相关复合物的重要组成成分,对有丝分裂后期的精准进行至关重要。但目前SKA3与肝细胞癌(HCC)之间的关系还尚不清楚。

研究人员采用GEO数据库(GSE62232,GSE45436,GSE6764和GSE36376)和TCGA数据库进行分析鉴定差异表达基因。通过CCK8细胞增殖毒性检测实验及平板克隆形成实验分析细胞的增殖能力,而通过划痕实验及小室(transwell)实验来分析细胞的侵袭能力。皮下移植瘤模型及肺转移模型则用于探讨SKA3在体内的作用。

生物信息学分析发现,SKA3高表达的肝癌患者的预后相对较差。同样的,对236个肿瘤样品进行免疫组化染色分析发现,SKA3的表达水平明显高于相邻正常肝组织。无论在体还是体外,下调SKA3的表达水平均能够显著抑制肿瘤的增殖及侵袭能力。

在机制上,研究人员发现SKA3可以通过细胞周期和P53信号通路进而影响肿瘤生长。敲低SKA3的表达可导致细胞分裂停滞在G2 / M期,甚至可导致严重的细胞凋亡;在HCC细胞中,抑制CDK2/p53磷酸化联合下调BAX/Bcl-2表达可具有相似效应。

总而言之,本研究揭示了SKA3在肝癌细胞凋亡和增殖调控中的作用,为解析肝癌的发生发展机制提供了新的信息。

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    2020-02-23 维他命
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    2020-12-12 zhaojie88
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topicName=CDK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Mon Oct 26 03:35:00 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871534, encodeId=461118e1534a5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Oct 09 07:35:00 CST 2020, time=2020-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372418, encodeId=7bb213e24183c, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435539, encodeId=48db143553966, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531506, encodeId=b3701531506b3, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377731, encodeId=30653e7731e7, content=学习了,天天大路通罗马啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Fri Jan 03 07:45:16 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-10-26 bioon1
  5. 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createdName=zhaojie88, createdTime=Sat Dec 12 00:35:00 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030759, encodeId=65562030e59de, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Tue May 26 02:35:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044927, encodeId=ae53204492ec2, content=<a href='/topic/show?id=e6b64401d0' target=_blank style='color:#2F92EE;'>#CDK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4401, encryptionId=e6b64401d0, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435539, encodeId=48db143553966, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), 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  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435539, encodeId=48db143553966, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-01-03 zhishijing
  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435539, encodeId=48db143553966, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Jan 03 14:35:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-01-03 zhouqu_8
  8. 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GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-01-03 cy0328
  9. 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GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-01-03 njwbhuang

    学习了,天天大路通罗马啊

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=377690, encodeId=52b63e76903d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Thu Jan 02 07:27:42 CST 2020, time=2020-01-02, status=1, ipAttribution=)]
    2020-01-02 Dr Z

    学习了

    0