Alzheimer&Dementia:全球成人早发型痴呆症的发病率趋势估计

2022-06-29 MedSci原创 MedSci原创

痴呆症通常被认为是老年人的疾病

痴呆症通常被认为是老年人的疾病,但它也可以发生在65岁以下的人身上,这被称为成人早发型痴呆症(YOD)。YOD的首发症状往往包括行为、语言、视觉或运动领域的困难。这类患者从症状出现到诊断为YOD的平均时间为4.4年,而晚发痴呆症(LOD)为2.8年。

目前尚缺乏关于年轻发病痴呆症(YOD)发病率的可靠数据,为此,来自荷兰马斯特里赫特大学的专家开展了相关meta分析,结果发表在Alzheimer&Dementia杂志上。

研究人员根据流行病学观察研究的Meta分析(MOOSE)指南,对1990年1月1日至2022年2月1日期间发表的基于人群的YOD发病率研究进行了系统回顾和meta分析。采用随机效应荟萃分析法对数据进行分析。结果按年龄标准化,并通过亚组分析和元回归评估异质性。

结果共有61篇文章被纳入。全球年龄标准化发病率从30至34岁的0.17/10万人增加到60至64岁的5.14/10万人,使30至64岁的全球总年龄标准化发病率为11/10万人。这相当于全世界每年有37万个新的YOD病例。

男性和女性的分层荟萃分析显示,发病率基本相似。对男性而言,粗发病率为38.3/10万人年,最低年龄组30至34岁的粗发病率为0.3/10万人年,最高年龄组60至64岁的粗发病率为60.8/10万人年。就女性而言,总的粗发病率为35.9/10万人年,最低年龄组30至34岁为0.6/10万人年,最高年龄组60至64岁为51.1/10万人年。

综上,该荟萃分析显示了目前对YOD发病率的最佳估计。

 

参考文献:

Global incidence of young-onset dementia: A systematic review and meta-analysis. https://doi.org/10.1002/alz.12695

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    2022-08-27 Boyinsh
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    2022-06-23 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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