Semin Arthritis Rheu:孕次、产次与患类风湿性关节炎风险之间的关联

2020-03-22 xiangting MedSci原创

这项系统评价不支持孕次和产次与患RA风险之间存在关联的说法。

这项研究通过系统地文献评价和荟萃分析,确定了孕次和产次是否与患类风湿性关节炎(RA)相关,并确定这种效应是否受到妊娠/分娩后所经过的时间、怀孕/分娩的次数和血清学状况的影响。

研究人员使用“类风湿性关节炎.mp”或“关节炎,类风湿性/”和“妊娠.mp”或“妊娠/”或“产次.mp”或“产次/”或“孕次.mp”或“孕次/”等术语检索Medline/EMBASE数据库(1946年至2018年)(过滤观察性研究)。纳入分析女性孕次/产次与RA风险之间关系的病例对照/队列研究。荟萃分析纳入将既往vs.从未怀孕/分娩女性RA效应量数据报道为ORs/RRs及其95%置信区间的研究。描述性分析了其他关联(如妊娠/分娩次数与风险的关联)。

20项研究(来自626篇文章)符合纳入标准,其中包括14项病例对照研究(病例4799例;11,941例对照)和6项队列研究(病例8575例;2,368,439人)。对报道了既往vs.从未分娩女性(OR 0.91;95%CI 0.80-1.04)和既往vs.从未妊娠女性(RA 0.86;95%CI 0.46-1.62)RA风险的研究进行荟萃分析没有观察到显著相关性。没有一致的证据表明妊娠/分娩次数与RA风险之间存在关联。正在妊娠中或刚刚分娩与RA风险之间未发现显著相关性。

这项系统评价不支持孕次和产次与患RA风险之间存在关联的说法。

原始出处:

Winnie M.Y.Chen. The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis Rheu. April 2020.

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    2020-03-24 lmm397
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    2020-03-24 zhaojie88
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