Nat Commun:发育中和无精症人类睾丸的单细胞分析揭示了支持细胞的核心作用

2020-11-22 AlexYang MedSci原创

非梗阻性无精子症(NOA)影响着1%的男性,由于对NOA发病机制和正常生精微环境了解不完整,目前对其治疗的临床疗效受到了限制。

非梗阻性无精子症(NOA)影响着1%的男性,由于对NOA发病机制和正常生精微环境了解不完整,目前对其治疗的临床疗效受到了限制。

最近,有研究人员对来自10名健康供体(从婴儿到成人)和7名NOA患者的>80000个人类睾丸单细胞的转录组数据进行了分析。研究结果发现,在睾丸微环境中形成支架的支持细胞(Sertoli细胞)在NOA患者中严重受损,并确定了支持细胞成熟的路线图。值得注意的是,先天性原因(Klinefelter综合征和Y染色体微缺失)患者的支持细胞是成熟的,但表现出异常的免疫反应,而特发性NOA(iNOA)的细胞在生理上是不成熟的。更多的是,研究人员发现,抑制Wnt信号传导可以促进iNOA患者支持细胞的成熟,从而使这些细胞重新获得支持生殖细胞生存的能力。

NOA患者中睾丸细胞从婴幼儿到成年的整体表达情况

最后,研究人员指出,他们的结果为NOA的诊断方法和治疗靶标的开发提供了一个新的视角。

原始出处:

LiangYu Zhao, ChenCheng Yao, XiaoYu Xing et al. Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells. Nat Commun. Nov 2020

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2021-09-27 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2021-09-19 liuli5079
  3. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2021-04-11 Tamikia
  5. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2020-11-24 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2020-11-24 zhangph
  7. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2020-11-23 ms8000002050640566

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1884805, encodeId=83cf188480595, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 27 19:20:23 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087828, encodeId=b6bf208e828ee, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Sep 19 09:20:23 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078722, encodeId=a31520e872230, content=<a href='/topic/show?id=0f145e0833a' target=_blank style='color:#2F92EE;'>#支持细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57083, encryptionId=0f145e0833a, topicName=支持细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Nov 28 14:20:23 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706322, encodeId=ca4e1e06322d5, content=<a href='/topic/show?id=a23f591051c' target=_blank style='color:#2F92EE;'>#无精症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59105, encryptionId=a23f591051c, topicName=无精症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46d131213490, createdName=Tamikia, createdTime=Sun Apr 11 21:20:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347515, encodeId=da77134e51593, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368404, encodeId=ea07136840420, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 24 06:20:23 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901495, encodeId=2b83901495e1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a35437702, createdName=ms8000002050640566, createdTime=Mon Nov 23 16:50:43 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901188, encodeId=ecda901188b7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sun Nov 22 15:40:20 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2020-11-22 ms3000000449926787

    好文章!

    0

相关资讯

Nat Commun:非阻塞性无精症三个新风险位点被发现

南京医科大学胡志斌教授、刘嘉茵教授、沙家豪教授和山东大学的陈子江教授发现三个新的中国男性非阻塞性无精症的风险位点,相关研究成果5月23日发表在国际著名的《自然通讯》期刊上。 据介绍,非阻塞性无精症又称睾丸衰竭症,是最常见的男性不育症类型之一,成年男性发病率约1%。研究人员在3608名非阻塞性无精症患者 和5909名正常对照人群中鉴别风险位点,发现了3个易感位点,分别是6p21.3

Hum Reprod:何时需进行精子冷冻

研究问题:在行ICSI前,何种情况下需要冷冻精子总结回答:单次射精精子总计数不足10^6时应行精子冷冻研究进展:由于个体的精子参数的变化,导致欲行ICSI(精子卵浆内注射技术)日时因精子不足被取消ICSI。精子冷冻技术可以避免这个问题,但鲜为人知的是决定冻结精子的条件。设计、规模、时间:这项回顾性研究纳入从2000到2012年间、247例接受精子冷冻保存以防ICSI时有无精风险的案例。 参与者/材

Fertil Steril:无精症男士容易患癌

  据《苹果日报》报道,美国一项研究发现患上无精症(Azoospermia)的男士,年轻时罹患癌症的风险较高。研究跟进逾2,000名平均36岁男士的生育情况,结果发现因患上无精症、令伴侣无法怀孕的男士,不但较生育功能正常的男士平均早10年患癌,罹患各种癌症的风险也高出三倍。无精症属严重的不育问题之一,估计困扰最少一成男士,暂无有效治疗方案。   研究人员估计癌症或是患者长期无法正常生产精子的后遗

2018 ASRM委员会意见:非梗阻性无精子症的治疗

2018年12月,美国生殖医学会(ASRM)发布了非梗阻性无精子症的治疗的委员会意见,用以替代2008年发布的《无精症的评估建议》。文章主要讨论了无精子症的管理内容。

Sci Rep:在一个大的巴基斯坦家族中,与X染色体连锁的AGDRG2变异和梗阻性无精症研究

最近,有研究人员在一个大的巴基斯坦家族中进行了全外显子组测序,并鉴定了一个引起镜子缺乏和男性不育的遗传病因。研究人员对3名不育的男性进行了精液分析、激素测试、睾丸组织学研究、超声诊断、染色体核型分析、Y染色体微缺失和CFTR测试。临床测试诊断为梗阻性无精子症(OA)。为了鉴定病因,研究人员对2名不育兄弟和2名课余家族成员进行了全外显子组测序(WES),并通过Sanger测序进行了分离分析和变异确定