Ann Rheum Dis:使用维生素K拮抗剂与骨关节炎发病和进展的风险升高相关

2021-04-19 xiangting MedSci原创

这些发现支持了维生素K和维生素K依赖性蛋白(如MGP)在OA发病中的重要性。

假设维生素K通过影响维生素K依赖性骨骼和软骨蛋白而在骨关节炎(OA)的发病中起作用,因此维生素K可能是一种可改变的危险因素。基质Gla蛋白(MGP)是一种维生素K依赖性蛋白的遗传变异体,可以抑制软骨钙化,与OA风险升高相关。华法林和新抗凝等维生素K拮抗剂抗凝剂(VKAs)通过抑制维生素K依赖性血液凝集蛋白起抗凝作用。VKAs也可能会影响其他依赖维生素K蛋白质的功能,例如MGP。

                                   

 

在3494名鹿特丹研究队列的参与者中,进行了新抗凝对OA发病和进展的影响研究。还分析了MGP和VKORC1单核苷酸突变对此关联的影响。

 

使用新抗凝与OA发病和进展的风险升高相关(OR=2.50,95% CI=1.94–3.20),分别为膝关节OA(OR = 2.34,95%CI = 1.67–3.22)和髋关节OA(OR = 2.74,95%CI = 1.82–4.11)。在新抗凝使用者中,携带高VKORC1(BB)表达单倍体以及MGP OA风险等位基因(rs1800801-T)的患者OA发病和进展的风险升高(OR=4.18, 95% CI=2.69–6.50),然而在非使用者中这种关系并不存在(OR = 1.01,95%CI = 0.78–1.33)。

                                              使用新抗凝与OA的发病风险

由此可见,这些发现支持了维生素K和维生素K依赖性蛋白(如MGP)在OA发病中的重要性。

 

原始出处:

Cindy G Boer. Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis. Ann Rheum Dis. April 2021.

 

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    2021-06-30 lisa438
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    2021-04-21 lmm397
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    2021-04-19 ms5000002050027133

    维生素K和维生素K依赖性蛋白(如MGP)在OA发病中的重要性。

    0

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