RNAi治疗COVID-19：Alnylam与Vir Biotechnology联手开发

2020-03-05 Allan MedSci原创

Alnylam Pharmaceuticals和Vir Biotechnology近日宣布，将扩大现有合作范围，以开发针对SARS-CoV-2病毒的RNAi治疗剂。Vir首席执行官George Scangos表示：“鉴于COVID-19爆发的范围和速度，Vir正在寻求多种方法，以迅速做出响应”。

Alnylam Pharmaceuticals和Vir Biotechnology近日宣布，将扩大现有合作范围，以开发针对SARS-CoV-2病毒的RNAi治疗剂。Vir首席执行官George Scangos表示：“鉴于COVID-19爆发的范围和速度，Vir正在寻求多种方法，以迅速做出响应”。

两家公司表示，将利用Alnylam在肺递送siRNA新型偶联物方面的最新进展，从而开发一种或多种siRNA来治疗SARS-CoV-2和其他冠状病毒。Alnylam首席执行官John Maraganore表示：“我们最近在肝外递送siRNA的临床前进展现已扩展到了肺部”。制药商指出，Alnylam已经设计和合成了350多种针对SARS-CoV和SARS-CoV-2基因组的siRNA。Vir将评估siRNA的体外和体内抗病毒活性，从而确定候选物。

RNA干扰（RNAi）是指一种分子生物学上由双链RNA诱发的基因沉默现象，其机制是通过阻碍特定基因的转录或翻译来抑制基因表达。当细胞中导入与内源性mRNA编码区同源的双链RNA时，该mRNA发生降解而导致基因表达沉默。

原始出处：

https://www.firstwordpharma.com/node/1705739

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2020-10-13 cathymary

#Biotech#

28 0
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2020-09-28 yinxm8315

#RNAi#

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2020-08-05 zz12341244

#Alnylam#

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2021-02-12 shock_melon

#TEC#

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2020-06-06 fzwish20000

#Technology#

36 0
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2020-06-14 lxg951

#LAM#

18 0
[GetPortalCommentsPageByObjectIdResponse(id=1927730, encodeId=75dc192e7301d, content=<a href='/topic/show?id=a59234e3b4' target=_blank style='color:#2F92EE;'>#Biotech#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3473, encryptionId=a59234e3b4, topicName=Biotech)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Tue Oct 13 06:40:00 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1751674, encodeId=ea0d1e51674b7, content=<a href='/topic/show?id=2c2c1553e56' target=_blank style='color:#2F92EE;'>#RNAi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15537, encryptionId=2c2c1553e56, topicName=RNAi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9d436366397, createdName=yinxm8315, createdTime=Mon Sep 28 13:40:00 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704838, encodeId=78a21e0483827, content=<a href='/topic/show?id=be56234245' target=_blank style='color:#2F92EE;'>#Alnylam#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2342, encryptionId=be56234245, topicName=Alnylam)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb930846673, createdName=zz12341244, createdTime=Wed Aug 05 06:40:00 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652404, encodeId=b6741652404fe, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Feb 12 10:40:00 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795607, encodeId=b15b1e9560711, content=<a href='/topic/show?id=87881e249e8' target=_blank style='color:#2F92EE;'>#Technology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17249, encryptionId=87881e249e8, topicName=Technology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Sat Jun 06 23:40:00 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057669, encodeId=dad5205e669d2, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jun 14 18:40:00 CST 2020, time=2020-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919007, encodeId=bf3c191900e51, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 13 14:40:00 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
2020-12-13 sunylz

#Bio#

20 0

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