Gastroenterology:不同食管腺癌表型患者的预后差异

2018-08-29 zhangfan MedSci原创

研究发现,食管腺癌伴巴雷特食管/肠上皮化生患者的预后较好,该研究结果对食管腺癌患者分层、临床治疗以及预后管理具有一定的指导意义

食管腺癌(EAC)患者疾病特征差异对生存期的影响显著,近日研究人员考察了EAC患者确诊时是否同时伴有巴雷特食管(BE)/肠上皮化生(IM)对生存期的影响。

Mayo队列以及UK队列患者参与研究,通过Cox比例风险回归评价BE/IM对EAC生存的影响,调整年龄、性别、TNM分期和肿瘤部位的影响。

411名Mayo队列EAC患者中,49.3%同时伴有BE/IM,其生存期优于无BE/IM患者(HR=0.44)。UK队列包含1417名患者,45%存在BE/IM,其生存期优于无BE/IM患者(HR=0.59)。多因素分析显示,EAC伴BE/IM患者生存期的优势不受年龄、性别、肿瘤阶段,位置以及病变长度的影响。

研究发现,食管腺癌伴巴雷特食管/肠上皮化生患者的预后较好,该研究结果对食管腺癌患者分层、临床治疗以及预后管理具有一定的指导意义。

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createdName=chaojitidian, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512285, encodeId=33541512285eb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, topicName=食管腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a7410453390, createdName=ms7899726347904398, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535184, encodeId=f3ae15351840b, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, 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  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504458, encodeId=b289150445871, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512285, encodeId=33541512285eb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, topicName=食管腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a7410453390, createdName=ms7899726347904398, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535184, encodeId=f3ae15351840b, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, 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    2018-09-14 许安
  6. 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createdName=chaojitidian, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512285, encodeId=33541512285eb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, topicName=食管腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a7410453390, createdName=ms7899726347904398, createdTime=Fri Aug 31 00:37:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535184, encodeId=f3ae15351840b, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, 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    2018-08-31 zhouqu_8
  7. 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  8. 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    2018-08-31 tastas

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