Am J Rhinol Allergy:鼻腔细胞学作为局部过敏性鼻炎的诊断工具分析

2019-06-07 AlexYang MedSci原创

局部过敏性鼻炎(LAR)可以通过皮刺试验(SPT)或者特异性血清lgE水平进行评估,具体表现为慢性鼻炎对过敏原的局部鼻过敏响应,且不存在全身免疫球蛋白(lgE)调控的疾病。鼻激发试验(NPT)是LAR诊断的黄金标准。鼻嗜酸性粒细胞是一种已知的过敏性鼻炎炎症标记。最近,有研究人员认为鼻嗜酸性粒细胞可以作为LAR的一种筛选标记并进行了验证。研究包括了48名具有常年非过敏性鼻炎(NAR)患者,且SPT为

局部过敏性鼻炎(LAR)可以通过皮刺试验(SPT)或者特异性血清lgE水平进行评估,具体表现为慢性鼻炎对过敏原的局部鼻过敏响应,且不存在全身免疫球蛋白(lgE)调控的疾病。鼻激发试验(NPT)是LAR诊断的黄金标准。鼻嗜酸性粒细胞是一种已知的过敏性鼻炎炎症标记。最近,有研究人员认为鼻嗜酸性粒细胞可以作为LAR的一种筛选标记并进行了验证。

研究包括了48名具有常年非过敏性鼻炎(NAR)患者,且SPT为阴性,并进行了鼻细胞学检查。研究人员利用3种过敏原(混合螨虫、混合蟑螂和百慕大草),并利用NPT对LAR进行了诊断。鼻症状组合鼻腔开放用来对NPT结果进行评估。另外,研究人员评估了鼻嗜酸性粒细胞的敏感性、特异性和阳性以及阴性预测值作为LAR诊断工具的情况。研究发现,LAR在41.6%的患者中诊出。鼻嗜酸性粒细胞在58%的NAR患者中发现。鼻嗜酸性粒细胞诊断LAR的敏感性为80%,特异性为57.14%,阳性预测值为57.14,阴性预测值为80%。其中,LAR最常见的过敏原为混合螨虫。

最后,研究人员指出,鼻细胞学检查时的鼻嗜酸性粒细胞因其敏感性和程序简单,是诊断LAR的良好筛选工具,而特异性低导致了NPT在LAR确诊是还是需要的。

原始出处:

Phothijindakul N, Chusakul S, Aeumjaturapat S et al. Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis. Am J Rhinol Allergy. 22 May 2019

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    2019-06-09 膀胱癌
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    2019-06-09 chg122
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    2019-06-09 mnda