Ann Rheum Dis:使用乌帕替尼治疗类风湿性关节炎的安全性

2021-02-24 xiangting MedSci原创

乌帕替尼是一种Janus激酶抑制剂,这项研究分析了治疗中重度类风湿关节炎(RA)时乌帕替尼的安全性。

乌帕替尼是一种Janus激酶抑制剂,这项研究分析了治疗中重度类风湿关节炎(RA)时乌帕替尼的安全性。

 

研究汇总了5项III期试验的治疗紧急不良事件(TEAEs)和实验室数据。计算了安慰剂(3项试验; 12/14周)、甲氨蝶呤(2项试验;平均使用时间:36周)、阿达木单抗(1项试验;平均使用时间:42周)、15mg(5项试验;平均使用时间:53周)和30mg(4项试验;平均使用时间:59周)的事件发生率。

3834例患者接受乌帕替尼治疗,其中15mg(n = 2630)、30mg(n = 1204)。上呼吸道感染、鼻咽炎和尿路感染是乌帕替尼最常见的TEAEs。15mg乌帕替尼与阿达木单抗的严重感染率相似,高于甲氨蝶呤。与甲氨蝶呤和阿达木单抗相比,乌帕替尼组的带状疱疹和肌酸磷酸激酶(CPK)升高的发生率更高,而乌帕替尼 30mg组的胃肠道穿孔率更高。各组的死亡率、恶性肿瘤、主要不良血管事件(MACE)和静脉血栓栓塞事件(VTE)的发生率相似。

 

与阿达木单抗相比,乌帕替尼患者带状疱疹和CPK升高的风险增加。乌帕替尼、甲氨蝶呤或阿达木单抗治疗的患者恶性肿瘤、MACE和VTE的发生率相似。

 

原始出处:

Stanley B Cohen. Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme. Ann Rheum Dis. February 2021.

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    2021-08-24 zhaojie88
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    2021-02-26 lmm397
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    2021-02-24 于冰馨

    学习了

    0

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    2021-02-24 1488a3f1m85(暂无昵称)

    优秀

    0

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