Diabetes Care:青年发病1型与2型糖尿病患者动脉硬度和心率变异性的纵向变化

2022-06-28 MedSci原创 MedSci原创

随着时间的推移,2型糖尿病患者和1型糖尿病患者以及具有代谢综合征特征的患者动脉硬化和HRV加重,变化更大。该危险因素谱证实了预防或限制青年糖尿病患者心血管并发症潜在可改变的途径。

儿童发病的1型和2型糖尿病患者中经常可以观察到心血管疾病危险因素,包括高血压、血脂异常和微量白蛋白尿。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在比较不同糖尿病类型的动脉硬化和心率变异性(HRV)随时间的变化,并确定了与青年糖尿病患者动脉硬化和HRV恶化相关的危险因素。

在青年糖尿病研究中,研究人员对青年期发病的1型或2型糖尿病患者的动脉硬化(脉搏波速度,增强指数)和6个心率变异性指标进行了两次测量,间隔4.5年。多变量线性回归模型用于评估随访时与动脉硬化和HRV相关的危险因素。

在1159名研究参与者中,949人患有1型糖尿病(平均年龄为17.1±4.7岁,60.3%为非西班牙裔白人,55%为女性),210人在初始评估时患有2型糖尿病(平均年龄为22.1±3.5岁,23.8%为非西班牙裔白人,71%为女性),当时糖尿病持续时间为7.9年(两组)。与1型糖尿病患者相比,2型糖尿病患者在初始和随访评估时动脉硬化和HRV异常更常见,且随时间变化更大(均P<0.05)。在这两种糖尿病的随访中,与动脉硬化和HRV恶化相关的危险因素包括高血压、糖化血红蛋白、腰围和甘油三酯随时间的增加和糖尿病持续时间的延长。

由此可见,随着时间的推移,2型糖尿病患者和1型糖尿病患者以及具有代谢综合征特征的患者动脉硬化和HRV加重,变化更大。该危险因素谱证实了预防或限制青年糖尿病患者心血管并发症潜在可改变的途径。

原始出处:
 
Amy S. Shah,et al.Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study.Diabetes care.2022.https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc21-2426/146998/Longitudinal-Changes-in-Arterial-Stiffness-and?redirectedFrom=fulltext

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    2022-12-13 docwu2019
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    2023-01-13 howi
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