Diabetes Care:心肌梗死后1型糖尿病患者的病死率分析

2022-06-28 MedSci原创 MedSci原创

1型糖尿病患者心肌梗死后的死亡风险高于非糖尿病患者。该研究的结果提醒人们注意大力预防1型糖尿病患者的心血管疾病。

血管疾病(CVD)是糖尿病的一个长期并发症。1型糖尿病患者发生心血管疾病的风险尤其高,他们发生心血管疾病的时间比没有糖尿病的人平均早10到15年。1型糖尿病作为心肌梗死的危险因素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估心肌梗死后1型糖尿病患者的病死率。

研究人员使用国家登记处探究了2005年至2018年期间芬兰20家医院收治的1型糖尿病(n=1935;41%为 女性;平均年龄为62.5岁)和无糖尿病(n=74671)的心肌梗死患者。感兴趣的结局是心肌梗死后1年内的死亡。研究人员通过多变量调整和倾向评分匹配来平衡组间差异。

1型糖尿病患者心肌梗死后30天(12.8% vs. 8.5%)和1年(24.3% vs. 16.8%)病死率高于倾向评分匹配的对照组(风险比为1.55;95%可信区间为1.32-1.81;P<0.0001)。在包括男性和女性、伴有和不伴有ST段抬高心肌梗死、伴有和不伴有血管重建术、伴有和不伴有心房纤颤、伴有和不伴有心力衰竭的亚组分析中,1型糖尿病患者预后较差。1型糖尿病的相对死亡风险在年轻患者中最高。老年、心力衰竭、外周血管疾病、肾功能衰竭和未见血运重建与MI预后较差相关。研究期间,1型糖尿病患者的病死率降低,但与无糖尿病患者的结局差异仍相似。

由此可见,1型糖尿病患者心肌梗死后的死亡风险高于非糖尿病患者。该研究的结果提醒人们注意大力预防1型糖尿病患者的心血管疾病。

原始出处:
 
Anne M. Kerola,et al.Case Fatality of Patients With Type 1 Diabetes After Myocardial Infarction.Diabetes care.2022.https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc22-0042/147067/Case-Fatality-of-Patients-With-Type-1-Diabetes?redirectedFrom=fulltext

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    2022-08-25 docwu2019
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