Nat Commun:前驱糖尿病与血管并发症之间的因果关系研究

2020-09-18 xiaozeng MedSci原创

前驱糖尿病是指低于2型糖尿病(T2D)诊断阈值的一种血糖失调状态。在全球范围内,约有3.52亿人患有前驱糖尿病,其中35%至50%的人在五年内发展成糖尿病。T2D及其并发症的治疗费用昂贵,这也导致相当

前驱糖尿病是指低于2型糖尿病(T2D)诊断阈值的一种血糖失调状态。在全球范围内,约有3.52亿人患有前驱糖尿病,其中35%至50%的人在五年内发展成糖尿病。T2D及其并发症的治疗费用昂贵,这也导致相当高的发病率和早期死亡率。前驱糖尿病与糖尿病并发症之间是否存在有因果关系还有待研究。

该研究通过因果关系分析,并辅之相关观察性研究分析,探讨前驱糖尿病在冠状动脉疾病、中风和慢性肾脏疾病中的作用。尽管观察性研究显示,前驱糖尿病与糖尿病并发症具有广泛相关性,但因果关系分析显示,前驱糖尿病仅与冠状动脉疾病有因果关系,没有证据显示其对其他糖尿病并发症有因果关系。

研究流程图

总而言之,该研究揭示前驱糖尿病可能引起冠状动脉疾病,并建议对前驱糖尿病提高重视,以便更早的预防糖尿病的发生。

 

原始出处:

Mutie, P.M., Pomares-Millan, H., Atabaki-Pasdar, N. et al. An investigation of causal relationships between prediabetes and vascular complications. Nat Commun 11, 4592 (14 September 2020).

 

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    2021-01-07 liuli5079
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    2021-04-23 丁鹏鹏
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    2020-10-07 liye789132251
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time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886600, encodeId=a668886600cb, content=非常的有启发性, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8QL5qCqiaNIibjhiap9ibmUibFuzH8iaVkVUdlxC2MCicfMaic36NkEaU8Yy3RMlmOoYv6ibDaA8IYKwrL1w/132, createdBy=ca822142637, createdName=Amby, createdTime=Sat Sep 19 11:15:52 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886595, encodeId=514f88659510, content=怎么预防?预防重于治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=528b5419391, createdName=ms7000001150800954, createdTime=Sat Sep 19 10:32:37 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-10-21 qingzipost

    值得学习!

    0

  5. 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likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:30:53 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886612, encodeId=4bb2886612bb, content=<a href='/topic/show?id=bfc73269828' target=_blank style='color:#2F92EE;'>#前驱糖尿病#</a>可能引起冠状动脉疾病!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32698, encryptionId=bfc73269828, topicName=前驱糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sat Sep 19 12:12:50 CST 2020, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2087776, encodeId=5437208e776a6, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Thu Jan 07 13:46:27 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758286, encodeId=74101e58286cd, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886600, encodeId=a668886600cb, content=非常的有启发性, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8QL5qCqiaNIibjhiap9ibmUibFuzH8iaVkVUdlxC2MCicfMaic36NkEaU8Yy3RMlmOoYv6ibDaA8IYKwrL1w/132, createdBy=ca822142637, createdName=Amby, createdTime=Sat Sep 19 11:15:52 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886595, encodeId=514f88659510, content=怎么预防?预防重于治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=528b5419391, createdName=ms7000001150800954, createdTime=Sat Sep 19 10:32:37 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-09-19 Nebula-Qin

    随着生活条件越来越好,糖尿病也越来越多了

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-09-19 Jessica

    #前驱糖尿病#可能引起冠状动脉疾病!

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-09-19 Amby

    非常的有启发性

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-09-19 ms7000001150800954

    怎么预防?预防重于治疗

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886581, encodeId=15b4886581fd, content=形势严峻, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded52568391, createdName=笑西风2019, createdTime=Sat Sep 19 08:54:10 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-09-19 笑西风2019

    形势严峻

    0

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在美国接受经导管主动脉瓣置换术的患者中,血管并发症和院内出血事件很常见,但其发生率随时间有所下降,并且各地医院的并发症发生率差异很大。血管和出血并发症均与短期和长期临床结局(包括全因死亡率)较差相关。

Am J Cardiol:浙医二院王建安Meta分析称,七因素与TAVI术后严重出血有关

浙江大学医学院附属第二医院王建安教授等公布的一项Meta分析提示,对于接受经导管主动脉瓣植入(TAVI)手术的患者,≥90岁、女性、鞘管直径>19 Fr、慢性肾脏病、经心尖途径、血管并发症和循环支持7个因素是术后早期严重出血的预测因素。

JCEM:2型糖尿病患者长期血糖变异性与血管并发症的关系

长期血糖GV与2型糖尿病患者的血管结局风险增加相关。

JACC:经股动脉经导管主动脉瓣置换术采用单侧入路是安全的

2014年至2017年期间,血管并发症明显下降。单侧入路的TF-TAVR与双侧入路的安全性相似,并且更容易对入路相关并发症进行管理,患者满意度更高。