Stroke:蔬菜硝酸盐摄入量与老年妇女颈动脉粥样硬化及缺血性脑血管病的关系!

2017-06-09 xing.T MedSci原创

独立于其他危险因素,较高的蔬菜硝酸盐摄入量与较低的CCA-IMT和较低的缺血性脑血管病事件风险相关。

短期增加饮食中的硝酸盐(NO3−)可以改善血管健康指标,通过生成一氧化氮和其它生物活性氮氧化物。但这是否会转化为长期的血管疾病风险降低尚不明确。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员评估了蔬菜来源的硝酸盐摄入量与老年女性(n=1226)颈总动脉内膜中层厚度(CCA-IMT)、斑块严重程度以及缺血性脑血管病事件之间的相关性。

研究人员测定了受试者基础(1998年)蔬菜硝酸盐摄入量、生活方式因素和心血管疾病危险因素。研究人员采用B型颈动脉超声测量了CCA-IMT和斑块严重程度(2001)。研究人员从西澳大利亚数据关联系统中获得14.5年期间(随访15032人次每年)完全缺血性脑血管病住院或死亡(事件)的数据。

研究人员发现蔬菜硝酸盐摄入量较高与较低的最大CCA-IMT(B=-0.015,P=0.002)和较低的平均CCA-IMT(B=-0.012,P=0.006)相关。在将生活方式与心血管危险因素进行调整后,这种相关性仍然显著(P≤0.01)。蔬菜硝酸盐摄入量不是斑块严重程度的预测因子。共有186名(15%)妇女发生了缺血性脑血管病事件。蔬菜硝酸盐的摄入量每增加每1SD(29mg/d),在未调整和调整的模型中,14.5年期间缺血性脑血管病事件风险降低了17%(P=0.02)。

独立于其他危险因素,较高的蔬菜硝酸盐摄入量与较低的CCA-IMT和较低的缺血性脑血管病事件风险相关。

原始出处:


Catherine P. Bondonno, et al. Association of Vegetable Nitrate Intake With Carotid Atherosclerosis and Ischemic Cerebrovascular Disease in Older Women.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.016844

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encodeId=556b19889108d, content=<a href='/topic/show?id=737ce226189' target=_blank style='color:#2F92EE;'>#盐摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72261, encryptionId=737ce226189, topicName=盐摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Apr 10 10:26:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860601, encodeId=a02b18606012b, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Nov 25 23:26:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944461, encodeId=f0a719444618c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Mon May 07 16:26:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756248, encodeId=a6a61e56248a3, content=<a href='/topic/show?id=0249e354370' target=_blank style='color:#2F92EE;'>#硝酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73543, encryptionId=0249e354370, topicName=硝酸盐)], attachment=null, 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    2017-11-25 lmm397
  8. 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  9. 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    2018-04-25 paperyu
  10. 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