Clinical Nutrition:肌肉质量减少对 COVID-19 患者呼吸机撤机和并发症的影响

2021-10-08 MedSci原创 MedSci原创

肌肉减少症,即肌肉质量和功能的丧失,这样的现象在呼吸肌中尤为明显,并且肌肉减少症与许多不良临床结果有关。

      肌肉减少症,即肌肉质量和功能的丧失,随着骨骼肌持续流失、强度和功能下降非常容易引起骨折以及关节损伤等问题。肌肉减少症还会影响器官功能,可能会引发心脏和肺部衰竭,甚至死亡。这样的现象在呼吸肌中尤为明显,并且肌肉减少症与许多不良临床结果有关。在本研究中,研究人员旨在评估减少的肌肉质量在预测因 COVID-19而入住 ICU 的患者的通气撤机、并发症、重症监护病房 (ICU) 时间以及住院时间和死亡率方面的作用。

 

       这是一项观察性研究,研究人员对米兰一家三级医院 ICU 病房的因COVID-19 患有肺炎进行插管的所有成年患者进行了相关研究。从常规胸部 CT 扫描中进行肌肉质量的测量。

 

      本项研究最后共招募了81名患者。肌肉质量与呼吸机成功拔管(OR 1.02, 95% CI 1.00–1.03, p = 0.017)、ICU 停留时间缩短(OR 0.97, 95% CI 0.95–0.99, p = 0.03)和住院死亡率降低(HR 0.98, 95% CI 0.96–0.99,p = 0.02)明显相关。肌肉密度与成功拔管相关(OR 1.07,95% CI 1.01–1.14;p = 0.02)并且与ICU并发症的数量呈负相关(Β -0.07, 95% CI -0.13 - -0.002, p = 0.03)、并且可以降低住院时间 (Β -1.36, 95% CI -2.21 - -0.51, p = 0.002) 和住院死亡率 (HR 0.88, 95% CI 0.78–0.99, p = 0.046)。

 

       本项研究证实利用常规 CT 成像来测量肌肉质量和质量可以是一种简单、廉价且强大的工具来预测 COVID-19 患者的存活率和疾病进展,但是治疗肌肉减少症最关键的还是运动,特别是抗阻运动。然后是基础营养支持,在提供充足的热量、微量营养素的基础上,保证优质蛋白的足量摄入至关重要。

 

 

原始出处:

Sarah Damanti. Et al. Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients. Clinical Nutrition.2021.

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    2022-05-02 丁鹏鹏
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    2021-10-09 Boyinsh
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    2021-10-09 zll0628

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