Environ Health:噪声峰度、NOX3遗传变异和生活方式与噪音诱导的听力损失相关性分析

2020-02-14 AlexYang MedSci原创

噪音诱导的听力损失(NIHL)是一种复杂的疾病,由环境和遗传风险因素引起。最近,有研究人员探索了噪声峰度、NOX3遗传变异和生活方式与NIHL的相关性情况。研究是一个案例对照研究,包括了307名NIHL患者和307名匹配的对照。研究发现,那些暴露在复杂的噪音中的参与者比那些暴露在稳定的噪音中的参与者具有更高的NIHL风险(调整后OR=1.806, P=0.002)。在NOX3 rs12195525

噪音诱导的听力损失(NIHL)是一种复杂的疾病,由环境和遗传风险因素引起。最近,有研究人员探索了噪声峰度、NOX3遗传变异和生活方式与NIHL的相关性情况。

研究是一个案例对照研究,包括了307名NIHL患者和307名匹配的对照。研究发现,那些暴露在复杂的噪音中的参与者比那些暴露在稳定的噪音中的参与者具有更高的NIHL风险(调整后OR=1.806, P=0.002)。在NOX3 rs12195525中,加性模型中的GT基因型和显性模型中的TT+GT基因型能够减少NIHL的风险(调整后OR=0.618, P=0.043; OR=0.622, P=0.036)。抽烟和接触高音量能够增加NIHL风险(调整后OR=1.486, P=0.038; OR=?.611, P=0.014)。相反地,常规的身体锻炼能够减少NIHL的风险(调整后OR=0.598, P=0.004)。研究人员在加性模型中发现复杂的噪音和生活方式(接触高音量和无身体锻炼)存在正相互作用(RERI=1.088, P<0.001; RERI=1.054, P=0.024)。另外,在加性模型中,NOX3 rs12195525 GG基因型与生活方式(抽烟和接触高音量)也存在正相互作用(RERI=1.042, P=0.005; RERI=0.774, P=0.044)。

最后,研究人员指出,噪音时空结构、NOX3 rs12195525多态性和抽烟、音量和身体锻炼3种生活方式与NIHL相关。他们的结果为NIHL的预防和遗传测试提供了理论基础。

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    2021-01-28 zhaojie88
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    2020-02-16 ysjykql
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time=2020-02-16, status=1, ipAttribution=)]
  5. 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time=2020-02-16, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1837791, encodeId=3ff1183e7917a, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Jan 10 08:06:00 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861358, encodeId=f3311861358be, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, 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time=2020-02-16, status=1, ipAttribution=)]
  7. 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likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Sun Feb 16 06:06:00 CST 2020, time=2020-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524295, encodeId=6a4f15242951a, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Feb 16 06:06:00 CST 2020, time=2020-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620382, encodeId=526f16203821d, content=<a 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time=2020-02-16, status=1, ipAttribution=)]
    2020-02-16 july_979
  8. 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    2020-02-16 xinmeili
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