Gut：肝硬化真菌菌群失调！

2017-06-04 xing.T MedSci原创

由此可见，在肝硬化患者中存在显著的真菌失调，其可被被抗生素和使用质子泵抑制剂所改变，但随着时间推移趋于稳定。合并的细菌-真菌菌群失调的指标，拟杆菌/子囊率，可以独立预测肝硬化患者90天的住院治疗情况。

肝硬化患者有较高的感染率，导致越来越多的真菌感染。而感染的肝硬化患者存在细菌菌群失调，真菌在其中的作用尚不清楚。近日，消化病领域权威杂志Gut上发表了一篇研究文章，研究人员旨在通过对门诊和住院肝硬化患者中进行横向和纵向的研究来评估肠道细菌和真菌菌群失调以及预测患者住院情况。

在横断面研究中：年龄匹配的对照组、门诊（有/无抗生素）和住院的非感染组、培养阴性和培养阳性的肝硬化患者被纳入研究，并随访90天。在纵向研究中：进行了3项研究：（1）肝硬化患者随访了超过6个月，（2）门诊肝硬化患者按照护理标准给予抗生素治疗5天，（3）肝硬化患者和对照者给予奥美拉唑14天以上。在所有的研究中，研究人员分析受试者的粪便细菌/真菌谱。

在横断面研究中，纳入了143例肝硬化患者和26例对照者，研究人员发现细菌和真菌的多样性存在显著相关。给予抗生素的门诊患者和培养阳性的感染患者其多样性最低。细菌和真菌的相关性在未感染患者中是相当复杂的，门诊和对照组患者显著向感染患者偏斜。在90天随访时21%的患者入院，拟杆菌/子囊比值较低与住院治疗发生率较低相关。在纵向研究中：真菌和细菌谱在随访期间（5 天-6 月）相对稳定。抗生素治疗后，可显著减少细菌和真菌的多样性，并可观察到较高的念珠菌以及较低的土著细菌相对丰度。奥美拉唑治疗后，细菌多样性和组成成分有所变化，但真菌的指标仍保持稳定。

由此可见，在肝硬化患者中存在显著的真菌失调，其可被被抗生素和使用质子泵抑制剂所改变，但随着时间推移趋于稳定。合并的细菌-真菌菌群失调的指标，拟杆菌/子囊率，可以独立预测肝硬化患者90天的住院治疗情况。

原始出处：

Jasmohan S Bajaj,et al. Fungal dysbiosis in cirrhosis. Gut. 2017. http://dx.doi.org/10.1136/gutjnl-2016-313170

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2017-07-30 188****7209

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2017-06-10 ylzr123

感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

61 0
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2017-06-06 虈亣靌

学习了，谢谢作者分享!

65 0
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2017-06-06 1e10c84am36(暂无匿称)

文章很好，拜读了

63 0
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2017-06-06 1dd7a091m35(暂无匿称)

牛逼。。。。。。

51 0
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2017-06-06 zhaojie88

#真菌#

23 0
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createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jun 10 08:24:11 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207341, encodeId=0d1b20e341b4, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:25 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207326, encodeId=754320e3263d, content=文章很好，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jun 06 12:55:27 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207297, encodeId=95e820e29758, content=牛逼。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Tue Jun 06 10:59:15 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353711, encodeId=fb741353e1172, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 06 05:48:00 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206805, encodeId=91f5206805ff, content=肝硬化能彻底治疗呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Jun 05 10:03:04 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206782, encodeId=7455206e82a5, content=好文，值得点赞，更值得收藏！慢慢领会学习的。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jun 05 09:32:34 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206680, encodeId=2c6520668059, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Jun 05 07:06:08 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206573, encodeId=fd732065e35a, content=什么都失调！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Jun 04 21:42:31 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
2017-06-05 flysky120

肝硬化能彻底治疗呢？

24 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 06 05:48:00 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206805, encodeId=91f5206805ff, content=肝硬化能彻底治疗呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Jun 05 10:03:04 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206782, encodeId=7455206e82a5, content=好文，值得点赞，更值得收藏！慢慢领会学习的。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jun 05 09:32:34 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206680, encodeId=2c6520668059, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Jun 05 07:06:08 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206573, encodeId=fd732065e35a, content=什么都失调！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Jun 04 21:42:31 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
2017-06-05 ylzr123

好文，值得点赞，更值得收藏！慢慢领会学习的。给点个赞！

28 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jun 05 09:32:34 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206680, encodeId=2c6520668059, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Jun 05 07:06:08 CST 2017, time=2017-06-05, status=1, ipAttribution=), 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2017-06-05 Y—xianghai

学习了新知识

24 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jun 06 12:55:27 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207297, encodeId=95e820e29758, content=牛逼。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Tue Jun 06 10:59:15 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353711, encodeId=fb741353e1172, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 06 05:48:00 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206805, encodeId=91f5206805ff, content=肝硬化能彻底治疗呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Jun 05 10:03:04 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206782, encodeId=7455206e82a5, content=好文，值得点赞，更值得收藏！慢慢领会学习的。给点个赞！, 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GetPortalCommentsPageByObjectIdResponse(id=206573, encodeId=fd732065e35a, content=什么都失调！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Jun 04 21:42:31 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
2017-06-04 thlabcde

什么都失调！

25 0